It's interesting to see that you say your CRPS has caused gastroparesis - are you/your doctors sure this is the case, or is it more due to the effects of the medications you're on. I'm not doubting you for a second by the way - I have GP caused by CRPS and nearly died as a result - also have other autonomic issues (brady- & tachycardia, severe orthostatic hypotension), but a lot of CRPS patients have a degree of delayed gastric emptying and aren't always aware that it is often caused by medications - opioids in particular are fairly notorious for causing this!
Ketamine - I have had four inpatient infusions. One was several years ago and caused a few problems with my heart so we gave up on the idea for some time. We tried again late last year and that gave me relief while in hospital, and for three days after, the others have given me nothing. One of my biggest problems is that I am extremely sensitive to it. A normal infusion dose as my doctor does it is anything from about
10mg/hr to 50mg/hr. I start getting very sick and dysphoric on 6mg... I consider it a treatment well worth trying for CRPS patients though - it Is very commonly done here and I know a lot of people who've been through it. Most experience at least a few weeks relief and I know of at least two who are still in remission several years on.
Your progression sounds like mine, once mine took off -
1999 - right knee
2005 - had more surgery on right knee > spread to rest of my right leg
2008 - entire left leg, back (following SCS revision surgery), both hands, arms
2008 - gastroparesis, tachycardia
2009 - nearly died from gastroparesis
2009/2010 - bradycardia/tachycardia, orthostatic hypotension
2010 - flares involving face
2011 - renewed involvement of both arms, shoulders, ribs, chest wall
As far as pathophysiology goes, there is a lot more being discovered. I have a recent article that covers a lot of interesting material. If you are interested, drop me an email and I'll send it to you.
Suzane, it's true that more females than males tend to be affected, but a great many men/boys are affected by this also. It's becoming more commonly diagnosed in children (I suspect probably because it's becoming better recognised) but I think it's most common among the middle aged. The 'good' thing about
CRPS in children is that they have a much higher rate of remission than adults - maybe because their nervous systems are still so dynamic and have the capacity to be retrained more easily?
Post Edited (CRPSpatient) : 8/22/2011 6:57:47 PM (GMT-6)