MAGNESIUM and ASHWAGANDHA may lower opioid tolerance

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spinal soldier
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Date Joined Dec 2009
Total Posts : 687
   Posted 12/27/2011 10:56 AM (GMT -6)   
in my research on NMDA receptor antagonist and lowering tolerance i came across Magnesium and a Ayurvedic Herb Ashwagandha which is also good for anxiety and fatigue. the standards for this treatment are DXM or dextromethorphan, Ketamine, memantine (Namenda) which all are potent drugs. has anyone heard anything about natural agents to lower tolerance?

cogito
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Date Joined Oct 2010
Total Posts : 932
   Posted 12/27/2011 11:47 AM (GMT -6)   
I've done quite a few google searches for agents that lower tolerance and you've listed the ones that appear most often. I presume you've done similar searches.

One more search you might want to try if you haven't yet is using clinicaltrials.gov and enter "opioid tolerance".
C4-T4 Scoliosis (disk degeneration, stenosis, narrowed neuroforamen, bone spurs), RT hip and SI joint damage from car accident. Also, pectus excavatum, supraventricular tacycardia and mitral valve prolapse syndrome.
Current meds: Ultram ER 300mg daily, breakthrough - hydrocodone 10-15mg, or oxycodone 5-7.5mg. .25-.5mg ativan as needed for sleep, Verapamil 240mg SR (for tachycardia). [/gray

spinal soldier
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Date Joined Dec 2009
Total Posts : 687
   Posted 12/28/2011 1:38 PM (GMT -6)   
i noticed your Verapamil for tachycardia, that might help your pain and lower tolerance but who knows. i have had a increase in pulse and blood pressure since Aug. when my insurance would not pay for generic Opana IR. i was getting 240 a month and that is cheaper than 60 Opana ER 40s. to make a long story short lack of pain control has effected my vitals. Jan 1 is a few days and i will have that Rx in hand. i look foward to less bedboundness.
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