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New Member

Date Joined Jun 2012
Total Posts : 1
   Posted 6/28/2012 5:32 PM (GMT -6)   
Hi---I suffer from Chronic Pain Syndrome, Osteoarthritis, Acromioclavicular arthritis, Fibromyalgia dengenerative disc disease (L5-S1) and lumber arthritis; not to mention I have problems with my left knee(needs replacement) and both my hips.  Today my pm gave me prescriptions for Nucynta 50mg. and Nucynta ER 100mg.  The pharmacy didn't have the ER in stock so I won't be getting that until next week.  I took my first 50mg when I got home over an hour ago.  I was an avid hydrocodone/percocet taker; my pm seems to think this is going to work for me---the only effect I'm feeling right now is tiredness.  How long should I expect to wait for results---still having a high level of pain at this moment.  Any infor would help. 

Veteran Member

Date Joined Oct 2010
Total Posts : 923
   Posted 6/28/2012 10:23 PM (GMT -6)   
Hi bestnana,

I've only used Nucynta a few times, and found that it helped with the pain (within 45 minutes), but always made me very drowsy (though I often still couldn't quite get to sleep). It targets not only the opioid receptors, but also is an NMDA antagonist and also affects serotonin and norepinephrine levels.

In theory, then, it should be a very effective medication, but alas, doesn't work for everyone.

Hope it helps & welcome.
C4-T4 Scoliosis (disk degeneration, stenosis, narrowed neuroforamen, bone spurs), RT hip and SI joint damage from car accident. Also, pectus excavatum, supraventricular tacycardia and mitral valve prolapse syndrome.
Current meds:20mg Oxycontin daily, Oxycodone 5-10mg for BT. .25-.5mg xanax as needed for sleep, Verapamil 240mg SR (for tachycardia).

Regular Member

Date Joined Jan 2012
Total Posts : 148
   Posted 6/29/2012 6:23 PM (GMT -6)   
Hello bestnana! Welcome to the boards!

My story is almost the same as yours- was on Percocet for years and it stopped helping me, so was switched to Nucynta a few months ago. At first I was given the regular Nucynta to take 3 times a day, but while it helped, it only helped for like 2-3 hours. My Dr then put me on the ER, which had always been the plan if the IR worked for me, to take every twelve hours and then the IR for breakthrough pain. My dosage is Nucynta 75 & Nucynta ER 100.....This medication worked quickly for me, but everyone is different. I have a lot of the same problems you have with your back, but that doesn't mean just because it helps me that it is going to help you.

One thing I have noticed though is that it's supposed to be a medication that doesn't need increases too quickly- what I mean is a person is meant to be on the same dosage a lot longer than other opiate's because the tolerance doesn't build as quickly with the Nucynta....So, with that being said, I already feel like it's not helping like it used to. I'm pretty upset with this as it literally seemed like a miracle drug to me and I don't want to have the dosage increased only after 3 months of being on it.

OK, sorry, I wrote a lot. LOL

I do hope it kicks in for you and does help with your pain! Good luck and keep us posted! smilewinkgrin
Current: Lumbosacral Spondylolysis, Lumbosacral Neuritis, Arthritis L3-S1, Facet Syndrome, SI Joint Dysfunction, Interstitial Cystitis, Vulvodynia, Restless Leg Syndrome, Bi-polar, IBS, Fibromyalgia, PTSD. On too many medication's to list & have had many surgeries & procedures and I'm only 34.
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