I would not be so quick to dismiss the low dose naltrexone. My doctor started me on LDN, in addition to ketamine infusions, over a year ago. Between the two I was able to get off of all opioids and antidepressants, and I now have FAR better pain control and quality of life than I ever did on opioids or any other medication. You are right that there have been no large double blind clinical trials done on LDN -- only small clinical studies with limited controls have been done -- and it is considered "experimental" for that reason. But there is actually quite a bit of scientific evidence in the primary literature showing that it works as a glial cell inhibitor, resulting in the reduction of inflammatory mediators within the central nervous system (which likely contribute to centrally mediated pain aka "central sensitization" -- often a major component of chronic pain -- among other things).
Yes, the LDN may not work for you, but if you are struggling so much with how things are now, then it may be worth a try. It has a very low side effect profile, and it certainly is a lot less harmful to your liver than massive doses of NSAIDs. Besides my professional medical training, I also also have liver issues myself, so I am VERY aware about
how any medication I take is metabolized (in fact I can't even take NSAIDs because of my liver issues). One thing is certain, though, if you continue taking NSAIDs like you are, it is pretty much only a matter of time before you end up with gastric ulcers, or worse, kidney or liver damage (at the very least you should DEFINITELY be taking omeprazole or another gastropreotectant with the ibuprofen).
If you have questions about
the LDN, a couple websites my doctor referred me to when I was first considering it are lowdosenaltrexone.org and ldnresearchtrust.org. It's your decision of course, but I will say that my doctor has been using LDN routinely in his patients (mostly CRPS patients, but other pain patients as well) for quite a few years now, and has had very good success with it, as have I, personally. Just something to think about
Post Edited (skeye) : 12/31/2016 2:43:46 PM (GMT-7)