Pain levels massively reduced...

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Veteran Member

Date Joined Oct 2010
Total Posts : 917
   Posted 10/5/2017 6:30 PM (GMT -7)   
HI everyone,

I used to be a regular here, but got irritated with someone and stopped posting.

Anyhow, I'm back because I want to share some great news, something that has made a huge difference for me.

I've tried dozens of supplements over the years and other than short-lived placebo effects, nothing helped...till this.

about 2.5 months ago, I started taking 250mg of agmatine 2x daily. Maybe it helped a bit. Then, a few weeks later, I added 25mg of tianeptine sulphate 2x daily.

Immediately, I was doing better and now, I'm doing great!

I was taking 300mg Tramadol ER, 10mg hydrocodone 2x daily (daytime)& 7.5mg oxycodone 2x daily(nighttime).

I'm still taking the Tramadol, but rarely take anything else. I'll still wake up with some pain, and have pain late afternoon, but rather than being in constant pain, just a couple breakthrough episodes, 0 or near 0 pain otherwise.

I had zero withdrawal too... though fear that won't be so with the Tramadol.

Last month, I had my PM cut my oxycodone script back. This month, I won't need anything but the Tramadol.

I have no clue if it is the combo or primarily the Tianeptine, but don't want to experiment yet. The two (morning, dinner) have been amazing. The only side effect was some constipation, which went away after about a week.

You can Google both supplements & discuss with your PM.

Lastly, check out Proglumide to roll back tolerance and help with withdrawal. I didn't need it, but had it on my list as a backup.

Elite Member

Date Joined Mar 2009
Total Posts : 20044
   Posted 10/5/2017 6:50 PM (GMT -7)   
good on ya. good to see ya posting again.

Veteran Member

Date Joined May 2014
Total Posts : 2076
   Posted 10/5/2017 7:59 PM (GMT -7)   
I will look them up, unfamiliar with them..always good to share things that help : )

Veteran Member

Date Joined Dec 2012
Total Posts : 679
   Posted 10/5/2017 8:47 PM (GMT -7)   
It is nice to see you posting once again. Welcome home.

I is always uplifting to read a post where someone, such as yourself, has gained relief from pain. I have made note of the supplements that have me benefitted you and am going to try one or both for myself.

Continued best wishes for less pain and more joy,
Pituitary failure, wide-spread endocrine dysfunction
Addison's disease
Mixed connective tissue disorder
Extensive intestinal perforation with sepsis, permanent ileostomy
Avascular necrosis of both hips and jaw
Receiving Palliative Care (care and comfort)

Veteran Member

Date Joined Oct 2010
Total Posts : 917
   Posted 10/9/2017 5:15 PM (GMT -7)   
Hi guys, a bit of an update...

I raised my tianeptine dose to see if I could get beyond the couple BT episodes I still have... but the extra dose made me feel dizzy. So, after 3 days of experimenting with modestly higher doses, today I took no tianeptine, had no dizziness, but my pain levels were up.

Finally, I took a modest 12.5mg of tianeptine before dinner plus 2.5mg of oxycodone after dinner.

One other BIG impact of my agmatine and/or tianeptine... I now need just 1/2 to a 1/3 of my BT dose. If you Google agmatine, you'll see that it is suppose to increase opioid efficacy and roll back tolerance.

Of course, our bodies differ, but I'm very curious to see if others get similar benefits.

From what I've read, it takes around 6 weeks for the agmatine to roll back tolerance, though the tianeptine worked within hrs.
C4-T4 Scoliosis (disk degeneration, stenosis, narrowed neuroforamen, bone spurs), RT hip and SI joint damage from car accident in 2004. Also, supraventricular tacycardia and mitral valve prolapse.
Time Release: Tramadol ER 300mg. Verapamil 240mg SR (for tachycardia).
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