A supplement that makes opioid meds more effective.

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Veteran Member

Date Joined Oct 2010
Total Posts : 932
   Posted 11/3/2017 4:22 PM (GMT -6)   
Hi all,

I posted some weeks ago about a couple supplements I've been using. They have significantly reduced my pain levels... but one of the two has also been shown through numerous studies to on its own potentiate opioid receptors so that meds are more effective -- as well as roll back tolerance.

So, any of you who are not getting adequate relief from your current meds, have a look at Agmatine (google "Agmatine and opioids").

From one research article:
"The most fascinating aspect of agmatine, an endogenous molecule, is its ability to potentiate the analgesic effect of morphine and at the same time to reduce the morphine dependence and withdrawal. The findings from this and previous reports suggest that increasing endogenous agmatine could offer novel therapeutic advantage in morphine analgesia and dependence. For example, combining agmatine with morphine during pain management, while reducing the effective dose of morphine, will also prevent the development of dependence to morphine."

You can get the equivalent of about 6-months worth of Agamatine from Amazon for about $15.

Elite Member

Date Joined Mar 2009
Total Posts : 20254
   Posted 11/4/2017 3:50 AM (GMT -6)   
interesting. thx.

New Member

Date Joined Nov 2017
Total Posts : 2
   Posted 11/4/2017 12:13 PM (GMT -6)   
Not really a supplement but Lyrica does help with opiod efficeny. You could also consider taking this Tryptophan though, to improve your sleep. It is not optimal but can be helpful sometimes.

Post Edited (limejuice1) : 11/7/2017 12:10:34 PM (GMT-7)

Veteran Member

Date Joined Oct 2010
Total Posts : 932
   Posted 11/4/2017 12:26 PM (GMT -6)   
There's also a number of research studies on proglumide as likewise rolling-back tolerance... as well as working as an opioid receptor agonist.

Proglumide, however, needs a prescription... it was many years ago a medication used for ulcers.

Regarding Lyrica, it helps with pain, but I haven't seen studies that indicate that it boosts opioid efficacy or rolls back tolerance.

The main reason I'm focusing on Agmatine is because it doesn't need a prescription and can be bought easily just to try.

I wish I could say that all my pain is gone, but I still have my usual BT episodes.... I now only need a fraction of the same meds, and between these episodes can often be pain free.

I'm taking both Agmatine and Tianeptine Sulfate -- the latter is also a supplement -- and is suppose to itself help with pain (and mood).
C4-T4 Scoliosis (disk degeneration, stenosis, narrowed neuroforamen, bone spurs), RT hip and SI joint damage from car accident in 2004. Also, supraventricular tacycardia and mitral valve prolapse.
Time Release: Tramadol ER 300mg. Verapamil 240mg SR (for tachycardia).
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