There's also a number of research studies on proglumide as likewise rolling-back tolerance... as well as working as an opioid receptor agonist.
Proglumide, however, needs a prescription... it was many years ago a medication used for ulcers.
Regarding Lyrica, it helps with pain, but I haven't seen studies that indicate that it boosts opioid efficacy or rolls back tolerance.
The main reason I'm focusing on Agmatine is because it doesn't need a prescription and can be bought easily just to try.
I wish I could say that all my pain is gone, but I still have my usual BT episodes.... I now only need a fraction of the same meds, and between these episodes can often be pain free.
I'm taking both Agmatine and Tianeptine Sulfate -- the latter is also a supplement -- and is suppose to itself help with pain (and mood).
C4-T4 Scoliosis (disk degeneration, stenosis, narrowed neuroforamen, bone spurs), RT hip and SI joint damage from car accident in 2004. Also, supraventricular tacycardia and mitral valve prolapse.
Time Release: Tramadol ER 300mg. Verapamil 240mg SR (for tachycardia).