Update on my supplements (opioids more effective, pain reduced).

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Veteran Member

Date Joined Oct 2010
Total Posts : 924
   Posted 2/22/2018 1:15 PM (GMT -6)   
Hi all,

I posted some months ago about a few supplements I've been using...
Agmatine 250mg 2x daily; Tianeptine Sulphate 25mg 2x daily.

I wanted to post an update -- I'm still using both and their benefits continue.

I also want to encourage others to check them out. I know that you can find tons of claims around about this or that supplement, but maybe these will work for you. Both are quite cheap. Agmatine is very very cheap (pennies a dose) and easy to find online. Tianeptine is sold at most "nootropic" websites and will cost you around 25-50 cents per dose.

The main purpose of the Agmatine is to roll-back opioid tolerance (google it) -- basically, after a decade of opioid use, I'm now finding 2.5mg of oxycodone enough for BT pain. The Agmatine is also suppose to directly help reduce pain, but I can't say for sure about that aspect of it. For the Agmatine to roll-back tolerance (apparently by restoring downregulated receptors), you'll need to take it for at least 3 weeks.

Consider this as an option also if you're taking high opioid doses and/or constantly struggle to ration your month's prescription. You might find that you'll get the same benefit out of a lower dose and thus not have to struggle stretching your prescribed pills through until your next PM appointment!

The Tianeptine, though, works right away. It helps especially with nerve pain. In the past, I usually would have constant pain down my left arm and left side of my back. It is 99% gone. Perhaps once a month or so I would feel it again, but it just barely noticeable vs. imposing itself on my consciousness.

Note that I'm still taking Tramadol ER 300mg, and a small BT dose some mornings and some evenings. But the constant nerve pain is nearly gone and I only now deal with a couple bouts of muscle pain (when I first wake up, and after a day at my desk).

Two other supplements for chronic pain I think look very promising:
Palmitoylethanolamide and Emoxypine. Google them. They're next on my list to try.

I've discussed all this with my PM and he's very pleased by my discoveries. I've asked him over the months if he's recommended them to any of his patients and he squirms a bit -- choosing his words carefully, he tells me that most of his patients are entrenched in their belief that ONLY opioids are capable of helping with their pain. I think the idea is that they feel that if something lesser helps, then it implies their pain wasn't legitimate or their use of opioids wasn't necessary. I understand -- but why not see if you can get even MORE relief from the pain?

p.s. A few weeks ago, I found a supplement alternative to benzodiazepines too. My PM won't allow benzodiazepines for anyone on opioids (due to the FDA back-box warning). He has, though, oked the alternative I found, even though it has the same mechanism of action. I don't want to post here, though, as it will distract from the above. But google around. I often have trouble getting to sleep due to anxiety and it works as well as xanax for me.
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