I think they now have identified many of the genes, immunefactors, and bacteria that combine to cause the disease.
The colon and the small intestines are "colonized" by bacteria, viruses, and fungus. Many are harmless, but a bacterium can change and become virulent. Common bugs can turn aggressive, manages to attach itself and invade the cells lining the small intestine
where it can trigger Crohn's disease in genetically susceptible people.
When you're healthy a bacteria invade the intestinal cells, the immune system typically kicks in
and try to get rid of them.
Are you genetically predisposed your immune system may get its signals crossed and overreact, leading to uncontrolled inflammation, or fail to kill the invader, leading to an ongoing infection.
1.Our immune system may lead to a decrease in a persons ability to kill bacterias.
2. Our immune system may lead to an overactive T-cell response to bacteria or bacterial antigens
3. The immune dysfunction may manifest itself as an inability to tolerate the presence of commonly
tolerated bacteria; or
4. this dysfunction may manifest itself as changes in the intestinal cells that make it easier
for bacteria to attach to them.
So the MAP bacteria in the milk could as well be a possible theory. They have found MAP bacteria from cows milk in 75 % of people with Crohn's, they have found it in 26 % in other people. May be nr. 3 could be an explanation due to MAP? I don't mean it has to be MAP, the most common E.Coli could turn aggressive and be heavy to handle for genetic predisposed people. As we see Crohns may have different causes. Some may be genetic predisposed, some may only have a weak immune system with lower endorphine productions and so on.........Another triggers could be the casein protein in milk, it could be the gluten in wheat, it could be processed food disturbing cells with nitrites and MSGs that the body's cells won't recognize and therefore the body's cells can't fully digest them.
The most recent gene discovered is ATG16L1. This gene codes for a protein involved in a process known as autophagy.
"The word "autophagy" literally means "eating oneself." In biology, it can be understood as
the digestion within a cell of materials produced by that cell or from a bacterium engulfed by the cell. In people who have an abnormal variant of ATG16L1, the immune cells responsible for killing bacteria may not be up to the job, and bacteria may resist being destroyed. The discovery of ATG16L1 fits almost uncannily with recent insights into what goes awry in at least some
types of Crohn's disease.
A defect in ATG16L1 may lead to problems with autophagy, while a defect in NOD2—the first Crohn's susceptibility gene to be discovered, in 2001—may impair the ability to kill bacteria through another route: by causing a deficit in the secretionof defensins, proteins that specialize in bacterial killing. These two genetic defects correlate with two different routes into the development of Crohn's disease, and with the new molecular insights described above".
I think there are many factors that leads to both Crohns and U.C. Now the science have drawn the big lines, they have found some genetical causes and they are looking for more than one cause, they have also found a lot of interesting details, and they will be able to target new medications that suits the different factors that they have found plausible for these diseases.
Diagnosed CD June 2007. Have only used prednisone. Did make a difference while max dosed. Got my problems back when tapering.