Imuran Dosing Amount

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Regular Member

Date Joined May 2006
Total Posts : 214
   Posted 1/10/2008 8:31 AM (GMT -7)   
Hello all, quick question for those taking or that have taken Imuran in the past.
Last year i got off Pred at a dose of 200mg/day of Imuran, worked like a dream and kept me in remission for almost an entire year. Anyways, i had another flare in the November and i continued Imuran at a new dose of 225mg/day. about 4 days ago, after i tapered from 10mg/day to 7.5mg/day of Pred (and i missed a day of dosage because i am an idiot and put my meds in checked baggage on the plane instead of with my carry on, which the airline was delayed with) i started getting my D back after 6 weeks of perfect BM's and can feel my intestines started to do their thing again.
My question is has anyone ever been on more then 225mg/day of blood counts on Imuran have never gone up in the category of liver/kidney counts, and on 200mg/day it barely kept my WBC below the high range, so i am thinking of asking for another increase in Imuran, i am desperate to get off the Pred since i am sick of some of the side effects that i get (acne and recently slight stretch marks from working out with heavy weights). I figure as long as my liver and kidney counts are well within healthy range, whats the harm in cranking up the dose.
Have a doctors appointment this afternoon about it, in the mean time i am curious to hear other ppls storys

Veteran Member

Date Joined Apr 2005
Total Posts : 2346
   Posted 1/10/2008 12:09 PM (GMT -7)   
I was on imuran for 3 years. I was on 200mg. I am a 5'8" 150 lb female....just to give you an idea of my size. Have your dr. order the prom. propredict metabolite test to see if you are in the theraputic range without any toxicity.

Veteran Member

Date Joined May 2003
Total Posts : 9448
   Posted 1/10/2008 1:12 PM (GMT -7)   
I second the suggestion to have the Prometheus ProPredict Metabolite test done.

When I was first started on Imuran thru the U of M ImmunoSuppressant Monitoring Program, I was scripted for that Prometheus test at 1 month and every 3 months after that. After 18 months or so that was reduced to every 6 months or whenever I encountered a weight change and now is done only once a year or whenever I encounter a weight change. The regular blood tests for Heptatic Function, CBCs w/differential & platelets continue to be done every 3 months.

At one point after a weight loss altho my regular blood draw for the Imuran was all well w/in normal ranges, the Prometheus PPM test clearly showed I was well ABOVE therapeutic range and way into potential hepatotoxicity range. We dropped my dose accordingly and the next PPPM I was w/in therapeutic range but well below potential hepatotoxicity range.
I've been on Imuran since April or so of 2003.

Some people are like Slinkies... Not really good for anything, but they still bring a smile to your face when you push them down a flight of stairs.

Regular Member

Date Joined May 2006
Total Posts : 214
   Posted 1/12/2008 9:12 PM (GMT -7)   
Can someone give me a little literature to read on this Prometheus ProPredict Metabolite, i have never heard of it before

Regular Member

Date Joined May 2006
Total Posts : 214
   Posted 1/12/2008 9:19 PM (GMT -7)   
I was reading the site for prometheous and it doesnt sound like these tests are available in canada? anyone know about that?

Veteran Member

Date Joined Jan 2003
Total Posts : 3169
   Posted 1/13/2008 5:50 AM (GMT -7)   
I am on 250 now but my doctor says that is the limit. It took that much for me to reach (just barely) the therapeutic level, per the Prometheus test, and, of course, my toxicity risk also rose. So now I am doing blood tests regularly and the doctor mentioned "giving humira a shot." I said, "Literally." The pun was unintentional but I appreciated it. I am not crazy about living on the edge with the immunosuppressant, and there's a chance I may lose my record of 25 years with CD and no resections, but records are made to be broken, right. What will be will be. Anyway, at one hospital in Baltimore they do the prometheus test and send it to California to be analyzed. Maybe that's a possibility in Canada. Good luck.
Take care. Lois
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