Prometheus results positive, colonoscopy clear (waiting for biopsy)

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New Member

Date Joined Dec 2007
Total Posts : 4
   Posted 1/10/2008 7:28 PM (GMT -7)   
Hello all,

I finally got my prometheus results which indicated pattern consistent with Crohn's Disease. All of my values were below the reference range (see below), which I thought was weird. I had a colonoscopy done and it came out clean, but I am waiting on the biospy. My GI ordered a small bowel follow-through. Which I get next week. Is it possible that the Prometheus test gave me a false positive for Crohn's and I am getting a bunch of tests for nothing?

ASCA IgA Elisa <12
ASCA IgG Elisa 21.5
Anti-OmpC IgA Elisa 11.7
Anti-CBir1 Elisa 18.2
IBD Specific pANCA
AutoAntibody ELISA < 12.1
IFA Perinuclear Pattern Not Detected
DNAse Sensitivity Not Detected

Veteran Member

Date Joined May 2003
Total Posts : 9448
   Posted 1/10/2008 7:31 PM (GMT -7)   
Its possible. Nothing is impossible, only highly improbable. On the other hand, the colonoscopy could be wrong, even the biopsy could be wrong and so could the SBFT. NONE of these medical tests are 100% accurate and reliable. They're just the best that the doctor's have at their disposal.
Back in 1976, even if colonoscopies had even existed then, they would NEVER have found my Crohn's if they'd done 100 of them because my Crohn's was confined to one small area in the MID ILEUM. Three SBFT's did indicate that SOMETHING was going on BUT the locals had no idea what it was or how to recognize Crohn's disease if they even knew what it was. It took a SBFT at Mayo Clinic in MN to Dx my Crohn's. And to know how to treat it.
As recently as 1999, neither a local colonoscopy nor a local SBFT indicated Crohn's activity, yet less than a month later a Mayo SBFT found and Dx'd not only active inflammation at the old resection site but also that my Crohn's had finally invaded my TI near the ICV. In fact, it was another 3 years or so before local colonoscopy could detect the inflammation at the TI/ICV that Mayo's SBFT found in 1999.

Some people are like Slinkies... Not really good for anything, but they still bring a smile to your face when you push them down a flight of stairs.

Post Edited (CrohnieToo) : 1/10/2008 7:38:27 PM (GMT-7)

Veteran Member

Date Joined Apr 2006
Total Posts : 1665
   Posted 1/10/2008 9:24 PM (GMT -7)   
my GI went to school with the guy who invented the promethius test and he says it is only about 65 % accurate--so much so that my doc won't have patients take it.
sorry you are going through this--it is so frustrating to not know what is happening! yp
48 y/o woman.  Diagnosed 4/06 after colonscopy, SBFT, CT-scan all showed crohns. 3 months later, after pred and remicade, all tests showed no crohns. In December had adhesions cut through a laparoscopy. Now just taking Glycolax, Ultra Fiber Plus and vicodin as needed.

Veteran Member

Date Joined Mar 2005
Total Posts : 2486
   Posted 1/10/2008 9:29 PM (GMT -7)   
My GI also puts not-that-much faith into it. Mine was negative but he still said that doesn't mean it's not Crohn's. The test is more specific than it is sensitive - meaning, if you have a positive result, that's a somewhat good indicator that you DO have the disease, but a negative result is a much better indicator that you DON'T have the disease. Does that make sense?'s one of those things that you can't really rely upon for diagnosis, ultimately, until the specificity/sensitivity increases, which is totally plausible in the future but not now.
Co-moderator - IBS Forum

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