Elevated Liver Enzymes

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Regular Member

Date Joined Oct 2006
Total Posts : 87
   Posted 1/28/2008 8:00 PM (GMT -7)   
Well my liver enzymes remain elevated.They have done an ultrasound,tested me for pbc ,and did blood work.Everything came back good but my blood work.They can't seem to figure out why mine are staying so elevated.Well my doc called me on Sunday afternoon and wants me to have a liver biopsy done to see if anything is going on that he can't see.He is worried because some people on remicade have had acute liver failure and some have even required a transplant. I have already had my gallbladder removed before dx with crohns.I have been on the highest remicade dose now for over a year and have always had slight reactions.I also have had a rash and itchiness for sometime now.He believes now that it could all be related to my liver.He has to do my liver biopsy under ultrasound guidance.I'm kinda nervous.
dx in oct 2006
entocort ec 9mg 1xday
remicade 10mg per kilo every 6-8 weeks
phenagren every 8 hours
dycyclomine 20mg 3xday
iron 325mg 2xday
calcium supplement
hydrocodone/apap 5mg/500mg 1-2 tabs every 4-6 hours
hydroxyzine 25 mg 1 tab every 4-6 hours
glycopyrrolate 2 mg every 8-12 hours

Veteran Member

Date Joined May 2007
Total Posts : 1488
   Posted 1/28/2008 8:41 PM (GMT -7)   
When have they got you scheduled? Hope everything is okay...must say being nervous would be a common reaction. Let us know how it turns out for you. (((Hugs)))
Dx'd Jan'06, 1st Resection 7/06, Predinsone, Humira, Imuran, B12 injections, Nexium. Secondary conditions: Psorasis, Acne, Fatigue, Joint Pain, Lactose Intolerant, gallstones, fibroid cysts, peri-menopausal.

Regular Member

Date Joined Dec 2007
Total Posts : 298
   Posted 1/29/2008 6:53 AM (GMT -7)   
I also know what you're going through... I had the same thing six months ago. I was having pain and fevers and some of my liver enzymes were elevated 2-3x, when a CT scan showed my liver was drastically enlarged, I spent four days inpatient while the doctors tried to figure it out. They thought I had Budd-Chiari (a blood clot in the liver). Had ultrasound, MRI, a ton of bloodwork, venogram through a vein in my leg, and a liver biopsy. I would describe the liver biospsy as quite painful--even the lidocane hurt, and I had to ask for more. But they stuck me four separate times and it was next to my belly button, whereas most people get it done through their ribs, so I think my experience was unusual.
They told me afterwards, since they had to go through muscle, it would not been have as bad if I was not so tense (can you blame me?) . So, if you are at all concerned about it I strongly suggest that you ask your doctor to give you something to help you relax before the procedure.
For me, my liver enzymes started going down as soon as I stopped taking oral contraceptives. I suggest you look at the side effects of all of the drugs you are currently taking and look for potential hepatotoxicity, even if they are generally considered safe.
Best of luck figuring this out :)

Post Edited (Confused in IL) : 1/29/2008 6:56:07 AM (GMT-7)

Regular Member

Date Joined Dec 2007
Total Posts : 298
   Posted 1/29/2008 7:21 AM (GMT -7)   
Just thought I would also mention regarding the liver biopsy:

Fatty liver is fairly common with Crohn's and that could be seen on the biopsy.

In my case what they saw is "centrilobular sinusoidal dilatation," which is consistent with a blood clot--hence all the other tests. But I never had a blood clot. What the doctors didn't know at the time, I suppose, is that this liver injury is also consistent with Crohn's disease. You can go on pubmed.gov and search these numbers to see some papers: 531518, 680504.

Just so that you (maybe) don't have to go through all that I did IF this is what the biopsy shows!

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