Yes, I've taken Pentasa since I was diagnosed in 2004. It obviously didn't do much for me considering my recent resection, with removal of 18 inches of TI and a grapefruit sized inflammatory mass. I was just at the GI today and she told me if I wanted to take the Pentasa that I could but there are no studies that really show it helps very much. She said the best chance for staying in remission would be the flagyl every day. I know it has some side effects, specifically the neuropathy but I think that might be better than living with active crohn's disease again.