new class of drugs for CD&UC - hydroxylase inhibitor ?!

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Date Joined Sep 2007
Total Posts : 37
   Posted 2/6/2008 4:52 AM (GMT -7)


The researchers discovered a new class of drugs known as hydroxylase inhibitors reacted with the gut to create protective pathways keeping cells that line the intestines alive.
The discovery was published in the scientific journal Gastroenterology and research by experts at the University of Colorado supports the Irish findings.


Has anyone heard of this? Any comments?


38 years old female, Dx'd July '06, Crohn's collitis and terminal ileitis,

Used Meds: Cipro, Flagyl, Sulfasalazine, 5ASA, 5ASA Enemas, Probiotics,B12 and Iron shots, blood transfusion, Urbason 60mg, Prednisone 20mg - Irigography, X-Ray Intesinal Passage, Colonoscopy in April 06, July 06, Hospitalized - Symptoms long before diagnozed (diarrhea, weight lost, fatigue, exhaustion, pain, subfebrile temperature, joint pain, especially knees)

Current meds: probiotics, prednisone tapering 30mg, sulfasalazine 3x1g, B12 shots, folic acid, omeprazole, xanax 2x0,25mg, alternative: royal jelly, tea mixture,

No surgery so far- History of Graves-Basedow disease in 1995

Regular Member

Date Joined Dec 2007
Total Posts : 298
   Posted 2/6/2008 9:51 AM (GMT -7)   
I also saw this recently.

I think that the hydroxylase inhibitor works by decreasing intestinal permability. Going on an exclusive enteral nutrition diet (elemental/polymeric liquid diet) can actually do the same thing, and is helpful for some people with IBD, particularly Crohn's in the small bowel.

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