I was put on Asacol and Prednisone at the same time. I have been on Asacol since July and have no physical side effects. You will notice that after a while of being on this med your urine will stain your toilet seat a sort of burgandy/brown so that's something to look forward to :)
As for the Prednisone, I had a whole bunch a symptoms from that but I was on higher dosages and took 5 months to taper. By the way, I had significantly less symptoms at 40MG and lower so you hopefully will have too much to worry about.
Everybody reacts to Prednisone a little differently, I never experienced much weight gain or puffy face but did have significant psychological side effects (insomnia, panic attacks, crazy mood swings).
Good luck...hopefully, the Asacol will be all you need to keep you healthy.
Dx with Crohn's Colitis July 2007
37 yr old working Mom with two beautiful little girls (2 and 4)
Prednisone (fingers crossed), 75 mg Mercaptopurine (6MP), 4.8g Asacol, lorazepam (1 MG), Vicadin, Imitrex and Ambien as needed
Other stuff: probiotics and folic acid