Posted 2/21/2008 7:25 AM (GMT -6)
MMMNavy, forgive my forgetfulness. Are you a male or a female? If female are you past child-bearing age? If you are past child-bearing age or are a male it would be worth your while to switch from Fosamax to Forteo.
Forteo is a once a day injection you give yourself that is part of a synthetic parathyroid hormone. I've had FANTASTIC results w/it the first 12 months I was on it. Even more improvement the second 12 months tho less dramatic and have opted to continue for a 3rd year on it tho at the present time it is only approved for 2 years of use.
There are many tricks to make the effectiveness of drugs sound impressive. If you take Fosamax you can be excused for thinking it lowers your risk of a hip fracture by 50 percent. That’s what the ads targeted to doctors claim. Fifty percent is a most impressive claim, which means that half the women taking it will benefit. One in two. Not bad, eh?
If you look closer at the actual study, you find that for women on placebo, two women out of a hundred had a hip fracture (two percent). In the women on Fosamax, one woman out of a hundred (one percent) had a hip fracture. In other words, you can lower your risk of hip fracture from two percent to one percent: an impressive 50 percent reduction? But 50 percent sounds impressive even though it is really only a one percent difference; that is, only one woman out of a hundred taking the drug saw any benefit. The company can promote this drug legally as being “significant” and “effective,” when, in fact, 99 percent of the women who took that drug had no effect whatsoever. They wasted their money, exposed themselves to the adverse effects of the drug and saw no benefit.
I refused to take the oral bisphosphonates due to their fairly common GI tract side effects and my Crohn's. My 1996 DEXA I had a T-score of -2.3 for the spine and T-score of -3.4 for the hip. by 2003 I had a spinal T-score of -3.2 and by 2005 it was -3.5 .
After 24 months on Forteo my last DEXA T-score for the spine was -2.2 and for my hip -2.7. During the time I've been on Forteo and for at least 6 months prior to starting Forteo I was on a scripted dose of 100,000 IU of vitamin D weekly, after a year or so on Forteo that dose was dropped to 50,000 IU of vitamin D weekly which I'm still on. During all this time I've not taken ANY calcium supplement because even just 300 IU of calcium constipates me. I'm one of the minority of crohnies prone to constipation rather than diarrhea.
There is regular blood work required before and after starting Forteo but since I'm on Imuran w/blood draws every 3 months for that we've made it a point to coordinate the timing.