I am on Humira, Imuran & for the past 2 years daily maintenance doses of predisone. As of last Saturday I was able to finally come off the pred! What other drugs do you take for the CD? The dosage of pred you have described sounds like the dose that is usually given during flares. I'm curious why you haven't been given the option of other supportive therapy? While I'm not familar with baker's cysts I might suggest you consider compression therapy strength hose to improve your circulation in your legs. Hopefully this will assist with the healing process. Compression knee highs can be fitted over any wound sites however would require an Rx from your doctor. Any compression hose less than Rx strength would not be therapeutic for you with the presence of swelling. The Humira as I'm sure you are aware could be keeping the baker's cyst from healing as well. I'd talk with my doctor about this. Any open wound while on Humira is not a good thing.