Starting Imuran and Nausea???

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Regular Member

Date Joined May 2006
Total Posts : 229
   Posted 3/18/2008 4:01 PM (GMT -7)   
Hey I was just put on imuran and i started at the 50mg dose just to see if it would effect my blood work and so far things were ok. But when i got the OK to go to the 150mg/day of imuran, i started to get the nausea and GI upset...Its been like almost 1 month since i first started the first pill of imuran...I heard this is an expected side effect...will my body get  used to this, or should I tell the GI to lower the dose or switch meds?...responses are much appreciated! thanks.

Regular Member

Date Joined Oct 2007
Total Posts : 235
   Posted 3/18/2008 4:14 PM (GMT -7)   
I've been lucky so far... no nausea from 100mg per day of Imuran. It seems to be evenly split between those that eventually get used to it, and those that have to discontinue it due to the nausea. Asking your GI if you can split the dose during the day can help. Also an anti-emitic like Promethazine (Phenagran) might help, too.

Just trying to be a "Regular Member".
Entocort 9 mg/day, Pentasa 4 gm/day, started Humira 1/22/08, started 100 mg of Azasan (Imuran) 2/20/08. I'm convinced that Prednisone is the root of all evil, and primarily responsible for global warming.

Veteran Member

Date Joined May 2007
Total Posts : 1488
   Posted 3/18/2008 8:20 PM (GMT -7)   
Splitting the dosage will help or do like I do...take it about an hour before I go to bed with a couple of saltines. That way it's not resting on my stomach and I sleep through any nausea or migraine that it causes me. I hate nausea and I hope my CD in my upper stomach never causes me anymore than necessary. Sometimes however, 2-3 times over the last year. I've been eating something and it comes back up with no warning. No burning, no nausea, no's like my stomach says...not today!
I'd try the phenagran too. If that doesn't work there are other anti-nausea drugs out there.
Dx'd Jan'06, 1st Resection 7/06, Predinsone, Humira, Imuran, B12 injections, Nexium. Secondary conditions: Psorasis, Acne, Fatigue, Joint Pain, Lactose Intolerant, gallstones, fibroid cysts, peri-menopausal.

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Date Joined Feb 2003
Total Posts : 15181
   Posted 3/18/2008 8:50 PM (GMT -7)   
When my gi first put me on Imuran he specifically said take it at bedtime because it can make you sick at your stomach. If I am reading your post correctly you went from 50mg to 150mg? Quite a jump, I would ask to try 100mg and then increase it to 150. Susie

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