I guess that I noticed a difference a few days after my first infusion, but didn't really start to feel a lot better until after the second, maybe third. (it's been a few years) I always remind myself that even if the drug works, there is already a lot of damage inside the intestinal tract and that will take time to heal. That's just my experience, though. Oh, but I never felt worse after an infusion... meaning I never got any flu-like symptoms.
--39 year old female, dx as UC in '04 (1st symptoms in '03), switched to Crohn's in '05
--1 fistula, crohn's colitis, limited to large intestine
--rejected (reaction/didn't work): Asacol, AZA, 6-MP, MTX, Remicade, Humira, prednisone
--stuck on methylprednisolone
--tried Prochymal in Phase III study (can't wait til it's approved!)
--waiting to start Tysabri
--single mom to 10-year-old girl