How do you know if you developed antibodies to the cade ?

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Veteran Member

Date Joined Feb 2004
Total Posts : 732
   Posted 3/20/2008 6:21 AM (GMT -7)   
As I get myself prepared to go back on the cade I have read alot about maybe developing antibodies do you know ?
Are there specific symptoms I should look for ?
Or does it simply not work ?? In that case when do we find that out ??
thanks !
Dx with Crohns 23 years ago
1 surgery ; 15 years ago ... 
Cervical DDD and restless leg syndrome
Currently on ;  Requip ,  Diovan ( for high bp )

Forum Moderator

Date Joined Apr 2007
Total Posts : 32602
   Posted 3/20/2008 6:58 AM (GMT -7)   

Good Morning,

This is a guess and I hope someone else knows the answer but perhaps the lab could do blood work to see if you have developed antibodies to this medication?

Sorry I don't have a definitive answer for you.  Happy Easter.

Kitt, Moderator: Anxiety ~ Panic  ~ Crohn's
Not a mental health professional of any kind
It is health that is real wealth and not pieces of gold and silver.~Mahatma Gandhi~

Veteran Member

Date Joined Aug 2007
Total Posts : 1202
   Posted 3/20/2008 7:54 AM (GMT -7)   
If you've developed antibodies, from my experience, Remicade starts decreasing in the effectiveness. So, an infusion will not last as long. The final, worst, sign is to have a reaction during an infusion. Remicade never lasted the full 8 weeks for me, but by the end I needed it every 4 weeks or I'd flare again.

Yes, there is a blood test by Prometheus Labs that will test for antibodies. They are expensive and not always covered by insurance, so you might want to look into that part first just to be aware of what you're asking for.
--39 year old female, dx as UC in '04 (1st symptoms in '03), switched to Crohn's in '05
--1 fistula, crohn's colitis, limited to large intestine
--rejected (reaction/didn't work): Asacol, AZA, 6-MP, MTX, Remicade, Humira, prednisone
--stuck on methylprednisolone
--tried Prochymal in Phase III study (can't wait til it's approved!)
--waiting to start Tysabri
--single mom to 10-year-old girl

Regular Member

Date Joined Aug 2003
Total Posts : 303
   Posted 3/20/2008 3:57 PM (GMT -7)   
I knew I developed antibodies because during my second infusion of Remicade, I had an allergic reaction (hives, throat closing up, turned bright red in the face and felt faint). I would also feel like my arms and legs were crazily heavy the 2 days after my infusions. I dealt with it by being premedicated before my infusions and having the drip set very slow. It took 5+ hours for my infusions.
Since I was off Remicade for so long (since December 2003) last year when I needed something more than the Imuran I was taking, my doctor wouldn't let me go back on it. He said I'd have more severe reactions. He put me on Humira instead and that's been great. :)
Dx in early 1999
Resection in June 2006
Currently on Humira

Veteran Member

Date Joined Mar 2006
Total Posts : 1034
   Posted 3/20/2008 6:26 PM (GMT -7)   
i believe you've developed antibodies when it stops working. i used to be able to go 6-9 months between infusions. when it took over a week for it work after an infusion and then a month later i couldnt wait for the next one, i knew i was in trouble...
Crazy Harry

Crohn's since 1993 (17 yrs old then)
surgery in July '05 - removal of 2 inches at ileum and 8 inches of sigmoid colon (had fistula into bladder)
Nov '05 developed colonic inertia; July '06 told i needed ostomy surgery
began maker's diet in August '06 - now feeling the best ever with no symptoms of colonic inertia and i kept my colon
med free as of 10/31/07

Forum Moderator

Date Joined Feb 2003
Total Posts : 15322
   Posted 3/20/2008 10:57 PM (GMT -7)   
You will know because it will not work. Having a reaction to Remicade is not developing antibodies to it. Back several yrs ago when I first started it I reacted on the 3rd infusion when they tried to increase the rate of the drip. It was stopped I was given IV Soluble Medrol & Benadryl. We waited a bit then resumed the Remicade at a slower rate and I had no further problems. From the on I was always given pre-meds & never had a problem. I did it for 3 1/2 yrs and we stopped because it quit being effective, my infusions were every 4 wks too. My gi said then I may have developed antibodies because it quit working. I just had a Remicade infusion last Friday for a fsitula, given pre-meds no problems at all. Ask your dr to order pre-meds. Susie

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