I was actually wondering the same thing myself. I have been on bi-weekly Humira for 6 months (plus 6mg. Entocort) now and up until a few weeks ago was touting about the wonders of modern medicine because I really felt better than I had in a long, long time. But now periods of feeling well are becoming less frequent and not lasting as long. I dread the thought of bumping up my Humira to weekly because the shot is so painful plus my insurance co-pay is quite high. I too, am just exhausted. Sorry I can't be of any help with your problems Trsora, but it seems we're in the same boat. Does anyone have any advice???