Problems with switching to Methotrexate

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New Member

Date Joined Mar 2008
Total Posts : 1
   Posted 3/31/2008 4:16 PM (GMT -7)   
I'm new here, so I'll give my requisite summary and make it brief:

I am 18 years old, diagnosed with Crohns Disease in August 2006, although I've probably had it for a few years beforehand. I'm on remicade, and as a consequence I was on Imuran until about two weeks ago when I switched to the weekly injection-based methotrexate. After my 2nd injection, I started having delibitating intense traveling joint pain. My knees, my ankles, toes, wrists, fingers, thumbs, elbows -- when I moved it, it hurt. It never stays in the same place, and completely destroys my ability to run, walk, or lift anything heavier than a book -- sometimes not even.
Oh yeah -- and my tongue feels like a rake went over it.
This is unusual for me. I don't usually encounter any serious pain. I have my occassional attack every once in a blue moon, but this is the first time that the joint pain has gotten out of control completely. Advice would be much appreciated.

Regular Member

Date Joined May 2003
Total Posts : 115
   Posted 3/31/2008 7:32 PM (GMT -7)   
Sorry, I don't have any advice to share with you. I take methotraxate, but in pill form, and I have never experienced any of those side effects. I'm just really tired often. I would definately talk to your GI about it.
The Greatest Discovery Of Any Generation
Is That Human Beings Can Alter Their Lives
By Altering The Attitudes Of Their Minds.

Veteran Member

Date Joined Sep 2006
Total Posts : 845
   Posted 4/1/2008 2:23 AM (GMT -7)   
I made the change from 6-mp to methotrexate injections about 6 months ago.  The first few injections were really similar for me as they have been for you.  My Rheumy upped my folic acid and that really helped with a lot of the symptoms.  Make sure that they are doing bloodwork on your liver because both remicade and methotrexate can really effect it.  I had to be taken off of both this past week due to elevated liver and pancreatic levels.

Veteran Member

Date Joined May 2005
Total Posts : 1362
   Posted 4/1/2008 2:51 AM (GMT -7)   
I think MTX can deplete your body of folic acid. It may not help the pain in your joints, but might help with your mouth problems. You should call your doctor and ask. Take care.
"Of one thing I am certain, the body is not the measure of healing - peace is the measure. ~George Melton~"

Current Meds include:Sulfasalazine and Zofran. With a new doctor, forced to retry all the meds that haven't worked in the past :(

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