From what I understand, and maybe what your doctor is suggesting, is that it is not uncommon for a person who does not respond to one TNF alpha blocker to not respond to the others. I lost response to Remicade, Humira never worked. My doctor said that when Cimzia does come out, it's unlikely to help me because my body seems to have stopped responding to the TNF alpha drugs.
Maybe you could ask your doc why you couldn't just try Remicade and then if it doesn't work move to Tysabri. Just wanted to let you know that my doctor said the same thing about Remicade/Humira/Cimzia... And, they all have hard side effects.
--39 year old female, dx as UC in '04 (1st symptoms in '03), switched to Crohn's in '05, 1 fistula, crohn's colitis, limited to large intestine
--rejected (reaction/didn't work): Asacol, AZA, 6-MP, MTX, Remicade, Humira, prednisone
--stuck on methylprednisolone, tried Prochymal in Phase III study (can't wait til it's approved!)
--started Tysabri 3/21/08
--single mom to 10-year-old girl