When I was on Remicade I did not have any side effects, except getting better. I felt fine during my infusion and after. I did, however, request a different antihistamine over Benadryl. Benadryl makes me sleepy, so I would take Allegra (or Zirtec) instead.
--39 year old female, dx as UC in '04 (1st symptoms in '03), switched to Crohn's in '05, 1 fistula, crohn's colitis, limited to large intestine
--rejected (reaction/didn't work): Asacol, AZA, 6-MP, MTX, Remicade, Humira, prednisone
--stuck on methylprednisolone, tried Prochymal in Phase III study (can't wait til it's approved!)
--started Tysabri 3/21/08
--single mom to 10-year-old girl