I've been on Humira since Jan 20 of this year. I started taking steroids again just about
a month ago, as Humira hadn't done anything for me up til that point. I'm down to 20 mg of Prednisone now, and I'm thinking the Humira must be doing *something*; the last time I tapered down to 20 mg of pred my CD symptoms came back with a vengeance, but I'm currently maintaining almost complete remission on 20 mg of pred. I also started taking Imuran (well, Azasan. Same thing) on Feb 20, but I think it's too early to give it any credit for helping the steroids.
When I took my "loading dose" of Humira, I did have a few flu symptoms and pretty yucky fatigue. Gradually the side effects have stopped. After my latest shot, which was a week ago, I only got a headache for a couple days. No fatigue, thank heavans. The fatigue I got as a Humira side effect was completely debilitating. I could hardly get out of bed for four days.
The doc has a steroid taper planned for me after I've been on the Imuran for three months. At that time, we're hoping that the Humira and Imuran will do the work of the steroids.
There have been alot of people say that Humira worked for them in as little as a week. The Humira web site says "as little as four weeks". And there's also been alot of people that said it took three months for Humira to help. So don't get discouraged if it doesn't work right away. :)