Imuran is known for causing stomach upset. Some people just cannot get past the yucky nausea feeling. Two things you could possibly bring up to your GI: 1) reducing the dosage and seeing if that helps reduce the symptoms you are having; 2)switching to 6MP. Some people that have trouble tolerating Imuran do very well on 6MP. Imuran is metabolized in the body into the mercaptopurine which is what 6 MP is.
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