aw sorry to hear about that survivor49. Your post stood out to me almost as if it were my own story. I am new to Imuran (azathioprine) but i was started at 50mg/day for a few weeks...and i was totally fine for that. but then after my first blood test I got the ok to go to 150mg/day...and only 2 or 3 days after that I noticed a rapid onset of a small to medium sized flare...I called my doc and he said to give it some time to work, and that my nausea would go away..but also some pains seemed to creep in too and reflux problems too a bit...so after about a month and a half on 150mg/day, I have quit the Imuran and I am about a 4 days into post-Imuran...I can't say my flare has subsided much at all yet, but it was somewhat...Yes...spring is bad for me often times, but this seems VERY coincidental considering i started to feel much worse 2 days after starting the imuran at 150mg. anyways, perhaps at my next visit my doc will just say the medication was just 'kicking in'...but ya...I'm really wondering if the damage the imuran did will be outweighed by the good it may do in 3 months after the dose increase....anyways, I will try to keep you posted if I start feeling better in another week or so from now...fingers crossed.