WHAT???? Two thirds of patients went into remission, 89% responded to tx.

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Date Joined Jan 2006
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   Posted 4/30/2008 3:23 PM (GMT -7)   
Why isnt there much talk about LDN? Can it be prescribed yet?
"Dr. Smith, Professor of Gastroenterology at Pennsylvania State University's College of Medicine, found that two-thirds of the patients in her pilot study went into remission and fully 89% of the group responded to LDN treatment to some degree"

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Date Joined Nov 2005
Total Posts : 1024
   Posted 4/30/2008 3:26 PM (GMT -7)   
Feeling really stupid right now???? What is LDN?


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Date Joined Apr 2005
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   Posted 4/30/2008 3:29 PM (GMT -7)   
look at the link....low dose naltrexone

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Date Joined Jan 2006
Total Posts : 303
   Posted 4/30/2008 3:31 PM (GMT -7)   
Its Narcan. What they give to folks with opiate overdoses. This drug has been around for decades and is harmless in low doses.
Low Dose Naltrexone, its not a "new Wonder" drug so there probabaly is not any money to be made.
Has anyone tried this. I start remicade next week and would live to try something a little less harsh.

Regular Member

Date Joined Apr 2008
Total Posts : 227
   Posted 4/30/2008 3:56 PM (GMT -7)   
Narcan is naloxone. Naltrexone is a different drug.

The big problem with the bright, new, shiny drugs for any chronic disorder is that it's a good idea to wait until there have been at least a couple of rounds of studies. It's good that Penn State has decided to chase this, and I sincerely hope they'll get some good data- AND FAST.

With diseases that tend to undergo remissive episodes like Crohn's, it's much tougher to gauge the efficacy of drugs like naltrexone. A three month study simply won't cut it. Unfortunately, longer studies also means a longer time before it can be handed down to patients.

Let's also not forget that for a chronic disorder like Crohn's, where a patient could spend years or even decades on the drug, some long-term safety data might be very nice. While naltrexone is a safe drug, it's not tough to imagine strange disorders popping up in Crohn's patients on LDN- stuff that might not get caught until 2-3 years after the drug is out there.

That having been said, I'm hopeful that something good will come of it. It would seem a relatively inexpensive treatment. If it proves effective and safe in long studies- perfect.

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Date Joined Jan 2005
Total Posts : 8616
   Posted 4/30/2008 4:01 PM (GMT -7)   
canuckgirl in the Lupus forum takes LDN.

I've heard some success stories from those with Lupus and MS.

If you go to the top of the page and type in LDN in the search window, you'll find lots of posts about it in the other forums.


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Regular Member

Date Joined Dec 2007
Total Posts : 63
   Posted 4/30/2008 4:26 PM (GMT -7)   

LDN is not FDA approved yet in low doses for Crohn's. There is an ongoing study at Penn Univ. that Crohnies have been discussing here. Not sure about the long term affects yet of this drug.


33 yr old Male from NYC, DX with Crohn's in oct of 1987, at age 13.
Resection in 1990 at age of 16.
Currently on Humira pen shots, 40mg once every 2 weeks. Cipro 2x a day.
Multi vitamin daily, Iron - 2x a day + B 12 pill 2x a day.

Regular Member

Date Joined Jul 2004
Total Posts : 92
   Posted 4/30/2008 4:27 PM (GMT -7)   

On the next page of this Crohn's forum, you'll see this topic with 2 pages of responses. (originally started by Ingrid of Norway)

Penn State University and Crohns Disease

I know there are folks on some of the spondylitis forums who are using LDN with success as well.




Regular Member

Date Joined Dec 2005
Total Posts : 267
   Posted 4/30/2008 8:08 PM (GMT -7)   
You have to remember that there was no placebo and it was a very small number of patients. I wouldn't be surprised that if they had a large multi-center controlled trial, less than 50% would go into remission. It had no effect on me (like everything else).

Regular Member

Date Joined Apr 2008
Total Posts : 195
   Posted 5/3/2008 2:31 PM (GMT -7)   
I know a lady who I talk to on dailystrength.com and she started LDN a few months ago and went from 15+ BM's a day down to 3 and she has no pain. I'm hoping I can get my hands on it, but it's a little harder up here in Canada where doctors are really strict with what they give out. I have a few docs up my sleeve so hopefully one of them will prescribe it to me.
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