Lyme can mimic Crohn's, down to the ulcers, bleeding, diarrhea, etc. Are you getting treated for Lyme? If so, this could be a herx reaction. Have you been tested for coinfections too? Lyme & coinfections destroy the immune system, and many people with inherited immundeficiencies have Crohn's-like inflammation in their gut because of their impaired immune system. Lyme also can paralyze the nerves that go to the gut, causing Gastroparesis and other dysmotility issues. Check out the following:
"Bell's Palsy of the Gut" and Other GI Manifestations of Lyme and Associated Diseases (by V. T. Sherr, MD)
What does Lyme Disease has to do with Digestion?
The ABC's of Lyme Disease, page 2, "Gastrointestinal Lyme"
Crohn's, Colitis, and Lyme Disease
And a book I recently finished reading, called "The Homeopathic Treatment of Lyme Disease" (by Peter Alex, Edited by Doug Smith), also says that Lyme Disease can mimic Crohn's Disease.
Known Gastrointestinal symptoms of Lyme Disease include swallowing difficulties, gastroparesis, constipation, diarrhea, blood in stool, heartburn, acid reflux/GERD, ulcers, abdominal pain, loss of appatite or always feeling hungry, weight loss or weight gain, etc. Lyme also causes a lot of other symptoms, including joint pain & inflammation, fatigue, low-grade fevers, etc., that can make it hard to distinguish from IBD.
And I personally believe the IBD Serology can be influenced by cross-reactivity between what the test was designed to detect and other organisms. Since Lyme (and co-infections) can change the proteins on their outer membrane surface, that means that they MIGHT be able to induce antibody formation that cross-reacts with other organisms. Also, ASCA are antibodies to yeast. Many of the treatments for lyme can lead to yeast overgrowth, which may induce antibody formation against yeast. I do not know if ASCA antibodies can cross-react with other yeasts, but I do think it is a possibility.
I myself have Lyme (and possible co-infections), gut inflammation, gastroparesis & other gut dysmotilities, etc., and my Lyme doctor says he does not think I have Crohn's, but rather Lyme-related gut problems.
I hope this helps...take care,
Gluten & Sulfite Sensitivity, Many Food/Inhalant/Medication Allergies & Intolerances, Asthma, Gut issues (dysmotility, non-specific inflammation), UCTD (Lupus?), Osteoporosis, Anemia, T- & B-Cell Lymphopenia, malabsorption/malnutrition, Lyme Disease (Igenex Lab IgM WesternBlot positive/CDC negative), etc.
Meds: Pulmicort, Injectable Vitamin B12, Herbs, Nutritional Supplements, Homeopathy.