I haven't done B12 shots, but MTX is an IM shot and I learned to do it myself in my leg. It was actually much easier than the Humira shots because there was no pinching to get subcutaneous and the shot itself didn't hurt like Humira. I prefered those IM shots over Humira! I would shake like crazy getting ready for giving myself a Humira shot. But, MTX was no big deal... *once* i got over the initial fears, which are totally normal! Poking yourself is not easy!
--40 year old female, dx as UC in '04 (1st symptoms in '03), switched to Crohn's in '05, 1 fistula, crohn's colitis, limited to large intestine
--rejected (reaction/didn't work): Asacol, AZA, 6-MP, MTX, Remicade, Humira, prednisone
--stuck on methylprednisolone, tried Prochymal in Phase III study (can't wait til it's approved!)
--started Tysabri 3/21/08
--single mom to 10-year-old girl