Biopsy report - giant cell....What is that?!

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Regular Member

Date Joined Apr 2008
Total Posts : 30
   Posted 5/19/2008 2:51 PM (GMT -7)   
I picked up my biopsy report today from 2000 when I was first diagnosed and it says there was an ill-defined granuloma with histiocytes and an occasional giant cell noted. What are these things? Has anyone had this come back on their report? I googled it and couldn't find much. Thanks for any help!
30 years old~ Diagnosed in 2000 with Crohn's~ Currently taking 3000 mg Pentasa, Prednisone, and Bentyl.

Regular Member

Date Joined Feb 2008
Total Posts : 91
   Posted 5/19/2008 4:25 PM (GMT -7)   
Hi Anna,

All I can do to help is to pass you these sites:

as for the giant cell I can't help you.

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Regular Member

Date Joined Dec 2007
Total Posts : 298
   Posted 5/19/2008 4:34 PM (GMT -7)   
Giant cells are basically macrophages. Macrophages are the immune cells that "eat" foreign particles like bacteria to neutralize them. In a nutshell...when you get a long-standing inflammatory response, the macrophages fuse together, and it becomes one enormous macrophage with multiple nuclei, aka a giant cell. This is seen in tuberculosis infection, which is a type of chronic granulomatous inflammation, similar to Crohn's disease.

Here's something from Wikipedia.
Add: It just means you had a chronic inflammatory process going on.

July 2007 Drug-Induced Liver Injury
January 2008 Crohn's Ileitis
Currently trying...
Enteral Nutrition, Omega-3 (Flax Oil and Fish Oil), VSL#3, Vitamin E, Folic Acid, Psyllium

Post Edited (Illini) : 5/19/2008 5:40:36 PM (GMT-6)

Mormor Vicky
Veteran Member

Date Joined Mar 2007
Total Posts : 684
   Posted 5/19/2008 8:57 PM (GMT -7)   
From what I understand that granulomas (giant cells) are abnormal cells and is a sign of Crohn's but not everyone has them. My daughter does but I don't.
Vicky / 48 years old
DX'd with Crohn's during a resection August 2006
DX'd with Steriod induced Diabetes November 2006
Considered in Clinical remission but have minor signs of disease activity
Daughter (27) also has Crohn's since she was 12.
Currently on 4000mg of Pentasa only for Crohn's
No longer able to take 6-MP because of Bone-Marrow Suppression
Cymbalta, Metformin, Lipitor

Veteran Member

Date Joined Mar 2005
Total Posts : 2486
   Posted 5/19/2008 11:48 PM (GMT -7)   
Ugh, I saw the words "giant cell" and had to respond even though I hate giant cells...yes, the giant cells make up the granulomas, which are pretty much a sure sign of Crohn's if found in the intestine...
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Please always remember to consult your medical professional regarding your medical questions; this forum is intended to provide patient-to-patient support. Although some of us have healthcare backgrounds, we cannot diagnose or treat patients on the board.

Regular Member

Date Joined Apr 2008
Total Posts : 30
   Posted 5/20/2008 11:59 AM (GMT -7)   
Thank you so much! I must not be a very good googler because I couldn't find anything! I'm glad to know it's not anything weird or unusual! Thanks again everyone!
30 years old~ Diagnosed in 2000 with Crohn's~ Currently taking 3000 mg Pentasa, Prednisone, and Bentyl.

Glad Bag
Veteran Member

Date Joined Mar 2007
Total Posts : 699
   Posted 5/21/2008 12:43 PM (GMT -7)   
that's a good one...."must not be a very good googler"
"I am he as you are he as you are me and we are all together!" - The Beatles

doesn't that just sound cool when you sing it?

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