Remicade and Methotrexate Questions

Anyone Taking Remecaide and Methotrexate Together to Combat Serious Chrohns?
Successul Combition ? - 50.0%
Unsuccesful Combition ? - 0.0%
Most common side effects to be aware of - 50.0%

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New Member

Date Joined Apr 2008
Total Posts : 2
   Posted 5/20/2008 9:49 AM (GMT -7)   
Dear Fellow Patients
I have been suffering with Chrohns for nearly two years at least. 
My GI Doctor just began me on a combitnation therapy of both 5mg of Remedicaide every eight weeks and
25 mg of Methotrexate every week via self adminstered muscle injections.  Has anyone else been on this medical regiment before.   To date, I have not responded well to other tradional therapies, and this seems to be my last hope with pharmacy products before serious surgery most be considered.
Would love to hear from all of you about success, not successful experiences and  side effects and anything else to be aware of.  Thank you so very much.
Post edited to include topic title for more responses :)

Post Edited By Moderator (AlwaysRosie) : 5/20/2008 11:31:12 AM (GMT-6)

Veteran Member

Date Joined Jan 2005
Total Posts : 8616
   Posted 5/20/2008 10:32 AM (GMT -7)   
Hi Seeking!

Welcome to the forum. I hope you don't mind, I edited your post to include a topic title so members who might be able to help will see your post.

Sorry, I can't offer any advice to help.


In His Grip

AlwaysRosie           "We can't control the waves, but we can learn how to surf!!"

Psalms 139

Co-Moderator - Lupus Forum

UCTD, Inflammatory Arthritis, Diverticulosis, (recent dx - Sjogrens, Crohn’s 4/08)

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Regular Member

Date Joined Apr 2007
Total Posts : 20
   Posted 5/21/2008 5:59 PM (GMT -7)   
Hey, after my first surgery my GI put me on remicade and it helped for a little while but wore off leading me to remicade after remicade. Eventually I was out of remission and after failing to control my CD despite surgery, I had a 2nd surgery. They put me on methotrexate and since then I've been in remission. Absolute wonder drug in my opinion, I haven't been on remicade with it though. If you drink, keep it to a bare minimum because methotrexate is very harsh on the liver as you will have to have your liver level checked every so often. When I first started taking it, I felt nausish but it only lasted for a day or so. Besides the liver, no real serious side effects on my side. Another side note, I took methotrexate in capsule form not injectable. If you can ask about the capsule if you have a had time with the injections. Good luck, hope it worked as well on you as it did for me!
18 Years Old 7/4/89
Diagnosed at age 12
Multiple medications including prednisone led to first surgery
Multiple medications including remicade led to second surgery
Remission since mid 2006

Veteran Member

Date Joined Dec 2007
Total Posts : 2113
   Posted 5/21/2008 6:32 PM (GMT -7)   
I haven't done Remicade but am on mtx-week 6-just got to full dose which for me is 6 pills every week-doc originally wanted to do 8 but I had some adverse reactions to dose 1 which was 4 pills and had to back down to two then go up by one each week.
Anyway, the adverse reactions did not come back as long as I take enough folic acid and I love the results.

New Member

Date Joined Apr 2008
Total Posts : 6
   Posted 5/21/2008 6:55 PM (GMT -7)   
I have done both remicade and mtx...originally, used them at different times, not as a combination as you've described. Later, I had problems with a rash all over my arms and neck (not a reaction to remicade or anything else...caused by the crohns). My dermatologist put me on mtx (still getting remicade for the crohns itself), and the mtx did help the rash for a while. It didn't do anything for my gut, though. I have used both the oral meds and given myself shots.

I think it may be difficult to tell which drug is effective if you began them at the same time??

Hope that helps!

Veteran Member

Date Joined Feb 2007
Total Posts : 734
   Posted 5/22/2008 7:29 PM (GMT -7)   
Hi, I was on Remicade and Methotrexate at the same time. Methotrexate replaced Imuran which gave me live issues. Methotrexate always left me feeling not so well and the day of injection wasn't fun. Remicade worked eventually and then after 5 years, stopped. Humira, seems to work much quicker and more efficient for me than Remicade ever did. My understanding of Methotrexate was that it was originally used as an abortion drug and breaks the immune system down. I just always felt crummy after injecting myself, I used tummy fat. Remicade worked pretty well for many years and then quit. So all in all, pretty good. Humira seems much better though. I hope I haven't caused too much confusion. Also, I had a hard time getting Methotrexate, the manufacturer quit producing many times.

Veteran Member

Date Joined Mar 2006
Total Posts : 1354
   Posted 5/23/2008 4:28 AM (GMT -7)   
Hi Seekinganswers,
I take 25mg MTX weekly and have been doing so for 2 years now. I havent done the Remicade - yet - so I dont know much about that. The MTX helps with my AS more than I think with the Crohns as when I went off it for two weeks last year for a resection my bones screamed. I do remember my Gastro saying that if I did the Remicade thing I would still be taking the MTX as they compliment each other. Sorry Im not much help.
Take care
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