Every time I taper down below the 5mg marker I get depressed, irritable and extreme fatigue. It hits about 3 days after the change in dose and lasts a little over a week. This last time I went very, very slowly and, while I still felt it, the process what easier at the end. Of course, now I am back on them, but...
Hang in there. It takes time for the adrenal glands to start functioning again, especially after so long on the steroids!
--40 year old female, dx as UC in '04 (1st symptoms in '03), switched to Crohn's in '05, 1 fistula, crohn's colitis, limited to large intestine
--rejected (reaction/didn't work): Asacol, AZA, 6-MP, MTX, Remicade, Humira, prednisone
--stuck on methylprednisolone, tried Prochymal in Phase III study (can't wait til it's approved!)
--started Tysabri 3/21/08
--single mom to 10-year-old girl