Has your mom tried Remicade? It is similar to Humira but delivered by IV. There is also Cimzia and Tysabri (only if all else fails!!!!) that she could try. Entocort is a steroid by mouth, so systemic, but metabolized quickly. it's also more effective for inflammation in the small intestine. If she's bleeding bright red, it's more likely from the large intestine. She might want to ask the doctor about prednisone instead of the entocort. Just a different steroid, but it will help the large intestine more.
I bleed quite a bit and am frequently low on blood. I've only had transfusions once, but I just sort of run low. There are also rectal meds that your mom could look into. The enemas will deliver meds directly to the rectal region(if that's where the bleeding is occuring) and that will help too.
Hopefully the referral will offer a fresh set of MD eyes to offer suggestions to your mom. It's tough living this way. it's great that you are so supportive!
--40 year old female, dx as UC in '04 (1st symptoms in '03), switched to Crohn's in '05, 1 fistula, crohn's colitis, limited to large intestine
--rejected (reaction/didn't work): Asacol, AZA, 6-MP, MTX, Remicade, Humira, prednisone
--stuck on methylprednisolone, tried Prochymal in Phase III study (can't wait til it's approved!)
--started Tysabri 3/21/08
--single mom to 10-year-old girl