Anyone here ever taken Methotrexate?

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Regular Member

Date Joined Nov 2007
Total Posts : 497
   Posted 6/3/2008 11:18 AM (GMT -7)   
Unfortunately my Scleritis came back and I get to take prednisone and methotrexate.  I have heard some scary things about methotrexate and I was wondering if any one has taken it or is on it? 

Veteran Member

Date Joined Mar 2007
Total Posts : 1642
   Posted 6/3/2008 12:37 PM (GMT -7)   
A lot of people here have taken it. Try a search and see what you get. I am on a sister med called Imuran (well the generic version) and I am glad I started taking it.


Karen (Karendee)

Diagnosed w/ Crohn’s Disease  March 2007 On 150mg Azathioprine (generic Imuran), Pentasa, & Entocort (take zofran for nausea now)

Diagnosed w/  Fibromyalgia May 2007 also on Soma

Also on Prilosec 2x a day for reflux.


Regular Member

Date Joined Nov 2007
Total Posts : 497
   Posted 6/3/2008 12:45 PM (GMT -7)   

Thanks Karen!  I am glad to know the sister drug is helping you!  :-)

I will do a search and see if I can find out more about the drug.

Veteran Member

Date Joined Dec 2007
Total Posts : 2113
   Posted 6/3/2008 3:42 PM (GMT -7)   
Hey the RA thread has an active thread telling stories about peoples early experiences with MTX. There is a lot of good information in there. Oh, make sure you take folic acid and drink lots of water.
I am on week 8 of mtx and although I resisted as long as possible and then whined through the first several weeks I am now doing great-have no side effects (I did the first several weeks) and am very glad I take it. (I am tapering off pred for the first time in 7 months).

Veteran Member

Date Joined Jul 2006
Total Posts : 6927
   Posted 6/3/2008 4:06 PM (GMT -7)   
love MTX shot
Forum Co-moderator - Crohn's Disease
We will find a way, or make one.-Hannibal (crossing the Alps in the 15th Century on war elephants) 
Make sure your suffering has meaning...-?
All suggestions/options/opinions are caveated with please consult with your local health care provider...

Veteran Member

Date Joined Mar 2006
Total Posts : 1354
   Posted 6/3/2008 4:55 PM (GMT -7)   
I take 25mg MTX orally and have done for two years now. The only complaint I have is hair loss (but that could be the pred too) otherwise all is good. Make sure you have blood tests every six weeks to check liver functions. I know the MTX helps my AS but not sure it goes much for my Crohns.
Take care

Regular Member

Date Joined Feb 2008
Total Posts : 91
   Posted 6/3/2008 5:32 PM (GMT -7)   
I am back on methotrexate and thankful for it every day. I have also taken every drug that is on the market for Crohn's, Ankylosying Spondylitis and Uveitis. There are good and bad in all drugs. Not everyone has a reaction to them. When a person has a reaction the doctor has to inform the drug company after a number of the same results (small number) the drug company has to report it. It may only be 2% of the poeple taking the drug that have reactions but they need to be reported and documented.

CD diagnosed 34 years ago
Stem Cell Transplant may be back on
Lap-assisted Ileocolic Resection- February 2008
Ankylosing Spondylitis
Back on Prednisone - I hate it
Ranitidine HCL 
Prednisone 1% (eye drops)
Maxidex  (eye ointment)
Homatropine 5% (eye drops)
B12, Folic Acid, Vitaman D, Calcium

Regular Member

Date Joined Jul 2005
Total Posts : 393
   Posted 6/3/2008 6:57 PM (GMT -7)   
Ive taken Imuran several times, and had no adverse reactions and it worked pretty well. Im hoping to go back on it. Alot of docs are sceptics cuz it causes impaired immunity, but I only noticed runny noses! lol

Anyone can give up, it's the easiest thing in the world to do. But to hold it together when everyone else would understand if you fell apart, that's true strength

Diagnosed with severe Crohn's colitis in May 2005--spread to ileum and small intestine as of April 2008. Have taken Imuran, Remicade, TPN, Colozal, Entocort, Flagyl, PamineForte, Cipro, Dicyclomine, Prednisone, Asacol, Prevacid, and the list goes on. Currently on Remicade every 8wks, 40mg Pred, Pentasa.

Regular Member

Date Joined Nov 2007
Total Posts : 497
   Posted 6/3/2008 7:57 PM (GMT -7)   
Thanks everyone!  I feel a lot better hearing how the drug helps and is good!  I am hoping that once the prednisone clears up my eye that the MTX will keep the Scleritis from coming back!  I guess only time will tell. 
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