Sore mouth and methotrexate??

New Topic Post Reply Printable Version
[ << Previous Thread | Next Thread >> ]

Regular Member

Date Joined Nov 2007
Total Posts : 497
   Posted 6/20/2008 4:25 PM (GMT -7)   
I have been on Methotrexate for about 3 weeks now, well 3 doses, and for the past few days, my entire mouth, tongue, is very tender and it feels raw and I have a metallic taste in my mouth.  I am really tired too.  Has this happened to those of you who are also on it?
Thanks a bunch!

Veteran Member

Date Joined Jan 2005
Total Posts : 8616
   Posted 6/20/2008 4:46 PM (GMT -7)   
Are you taking folic acid??? The doctor should prescribe a certain amount for you to take daily. The MTX uses up this nutrient and lack of it can cause mouth sores. Folic Acid also protects your heart from a possible problem from the mtx.

Sorry you are having trouble.


In His Grip

AlwaysRosie           "We can't control the waves, but we can learn how to surf!!"

Psalms 139

Co-Moderator - Lupus Forum

UCTD, Inflammatory Arthritis, Diverticulosis, (recent dx - Sjogrens, Crohn’s 4/08)

Clickable Links:  Lupus Resources    Lupous.Org   Lupus Criteria (4 of 11)   Lupus Chapter Locator

Elite Member

Date Joined Sep 2005
Total Posts : 10404
   Posted 6/20/2008 5:51 PM (GMT -7)   
Gargling several times a day with salty water might help.
Co-Moderator Crohn's Forum.

Veteran Member

Date Joined Dec 2007
Total Posts : 2113
   Posted 6/20/2008 6:11 PM (GMT -7)   
You need to take the folic acid it will get rid of the mouth sores and the fatigue. If you are taking some take more and see if that helps. Folic Acid is a water soluable vitamin which means their is very little danger of taking too much. I take 3 mgs per day and it eliminated my mouth sores and my fatigue. The folic acid will be even more important as your mtx dose is increased. I hope you feel better soon and that the mtx ends up helping you.

Regular Member

Date Joined Nov 2007
Total Posts : 497
   Posted 6/20/2008 6:56 PM (GMT -7)   

Thank you, thank you!!!  I am going to get some Folic Acid tomorrow and start taking it!  I am kind of surprised my doctor didn't mention getting the folic acid, but I don't think she usually prescribes MTX either.

Thanks again for all your replies!  :-)

Rider Fan
Veteran Member

Date Joined May 2008
Total Posts : 1445
   Posted 6/20/2008 7:01 PM (GMT -7)   
What kind of doctor are you going to?
Dx'ed in 1999. No surgeries.

Current meds: 75 mg 6MP. 20mg prednisone.  Udo's Choice Probiotics (30 billion).

Regular Member

Date Joined Nov 2007
Total Posts : 497
   Posted 6/20/2008 7:10 PM (GMT -7)   
Long story on the doctor(s)! Basically, I see an Internist and I have Scleritis and it flared up again 3 weeks ago. My Opthalmologist wanted me to start on the MTX instead of being off and on Prednisone every few months. Anyhow, he suggested me seeing the Rheumy I saw to get the MTX dosage right and I asked my Internist and she does not think too much of the Rheumy I saw (long story) and so she decided to prescribe it herself. Luckily, the 2nd GI diagnosed me with Crohn's and I have the small capsule done this coming Wednesday and after he finds out if I have small bowel disease, he will treat the Crohn's (wherever it is) and he seems to think I might be able to get off the pred and the MTX.

My Internist did say I will have to have blood tests and lung function tests every 3 months while on the MTX. She also said it takes the MTX about two months to start working. I am just hoping that if treating the Crohn's does not help me with the eye problems, that the MTX will. I am not the best of company when I am on prednisone to be honest. :)

Geeze, I feel like just getting down to the bottom of all of this has been a long journey!!!
New Topic Post Reply Printable Version
Forum Information
Currently it is Friday, November 24, 2017 2:23 AM (GMT -7)
There are a total of 2,897,371 posts in 318,008 threads.
View Active Threads

Who's Online
This forum has 157578 registered members. Please welcome our newest member, Clotaire.
199 Guest(s), 3 Registered Member(s) are currently online.  Details
Derwent, Girlie, Subdenis

About Us | Advertise | Donate
Newsletter | Privacy Policy & Disclaimer
Follow on Facebook Follow on Twitter Follow on Pinterest
©1996-2017 LLC  All Rights Reserved.