Mezavant, Side Effects?

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Date Joined Jun 2008
Total Posts : 49
   Posted 6/21/2008 5:06 PM (GMT -7)   
Hi everyone first post here, ive been suffering for about 11 months of chronic abdominal pain, was finally diagnosed last tuesday after an upper endoscopy and colonscopy. My GI specialist said it looked like UC except it spared my rectum, which is a little strange so his money is on crohns. He said that it didnt matter at this point because the treatment was the same. He prescibed me a new, very expensive drug mezavant.

I began taking it two days ago, first one pill then two the next day and three today. Im supposed to work my way to four in total. Last night around supper time I started feeling super groggy and could barely keep myself awake. Today I woke up and took my meds and a couple hours later I started to have some extreme anxiety and I got super tired. I could barely get off my couch all day, I slept all afternoon finally woke up felt alert for about 5 mins and now I feel dead again! It almost feels like having mono all over again... Ive also been feeling a little warm maybe pending a fever.

Could this be caused by the drug or its introduction to my body? Should I go down to emerg and talk to a doctor? (im in canada its free)

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Date Joined Nov 2003
Total Posts : 7122
   Posted 6/22/2008 8:56 PM (GMT -7)   

Welcome to Healing Well, abseeley! I'm sorry that you have been ill for so long. I was almost relieved when they finally came up with a name for my long term gut problems. Then I got anxious. What a rollercoaster of emotions....

Mezavant is a brand name of a medication used here in the US called Lialda. This medication is a long-lasting Mesalazine (5-aminosalicyd acid or 5-ASA). Mesalazine is a very common medication that people with CD and UC often take. Shorter acting mesalazine products are called Pentasa and Asacol.

In everything I have read, drowsiness is not a side effect of these meds. BUT people with sensitivity to aspirin could have some serious reactions to these meds. Please review the side effects list at the following site. If you have any that fall under the stop taking immediately section, do that and consult your doctor now. Mezavant Drug Fact Sheet

Moderator Crohn's Disease Forum
CD, Ankylosing Spondylitis, lupus, small fiber peripheral neuropathy, avascular necrosis, peripheral artery disease, degenerative disc disease, and a host of other medical problems.

Regular Member

Date Joined Jun 2008
Total Posts : 49
   Posted 6/23/2008 6:13 PM (GMT -7)   
Hi thanks for your reply, I ended up going down the hospital, good thing too I half fainted in the waiting room and the kind lady next to me helped me in time. They said there isn't an antidote for a tox emergency with that drug, so they told me to take it really easy and talk to my doctor asap. I did today and he said that just like in the past my body is very very sensitive to any drug introduced to it, (benzodiazepiens were rough!). And I know its a long lasting 5-ASA drug with an MMX coating to ensure delivery and avoid harming the stomach. I actually know quite a bit about pharmacology I was just in the biggest fog the other night, but your response was very detailed and simple to understand so kudos all the same. My doctor told me to ease off until my symptoms went away then to try taking one a day again to gradually adjust my body.
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