Time for 6MP to start working

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New Member

Date Joined Oct 2007
Total Posts : 9
   Posted 7/8/2008 7:59 PM (GMT -7)   
I am new to posting but have been following this forum for the last 6-12 months.  I have recently started 6MP due to refractory s/s of CD (also taking Pentasa + Entocort); My GI wanted me to start at 100 mg/d based on a normal TPMT test but I opted to titrate the dose up (under his discretion); I did 2 weeks of 50 mg/d then 2 weeks of 75 mg/d.  Just curious how long it took for everyone to see an effect.  My CD is not very patient.  I plan to up the dose this week to the target of 100 mg/d
Thanks for the input!

Veteran Member

Date Joined Jan 2006
Total Posts : 730
   Posted 7/8/2008 10:16 PM (GMT -7)   

6mp can take a while to build up in your system to levels enough to make a difference. It'll vary from person to person, but 3 months or so would be a good guess. Probably not the time line you were looking for.

I've been on 6mp for 5 years now, at least, along with Remicade. I'm 6'4" 250lbs, and 100mg of 6mp totally wiped me out. It made me so tired all the time I could barely function. I talked it over with my GI and after a few months of this I cut back to 50mg/day. That seems to be a pretty good level for me.

Also, since this drug is an immunosupressant, make sure to get regular blood tests done. It is very important that the doctors watch your blood counts, since 6mp can play havoc on your system.
Matthew McKenna,

"I'm just along for the ride."

Veteran Member

Date Joined Mar 2006
Total Posts : 1169
   Posted 7/9/2008 4:39 AM (GMT -7)   
Matthew is right. Been on 6mp for 6 years here (50 mg) with excellent results. But the window for it to reach full effectiveness can run from 3-6 months. So be patient and do get regular blood work and see where it takes yuo. I think the generally accepted rate of complications for 6 mp is aroind 10-15%, while from my reading on this board the percent of patients who report it being effective in controlling or at least significantly reducing CD symptoms is well over 75%.

Lady G
Regular Member

Date Joined Sep 2006
Total Posts : 321
   Posted 7/9/2008 11:55 AM (GMT -7)   
I started Imuran (same as 6mp) earlier this year and was told it takes around 3 monthes to work, I started the same way 50mg, to 100 mg to 150 mg by the month time then continued on that dose. But it does take a few monthes to really work.
27 year old, married. Diagnosed with Crohns at 17, suspected of having for at least a year or so before that.  Alot of Crohns in my family history.  No surgeries yet. Taking Imuran.

Veteran Member

Date Joined Feb 2003
Total Posts : 1811
   Posted 7/9/2008 12:40 PM (GMT -7)   
I've been on and off of it over the last 10 years or so and every time it has taken about 3 months to really feel the effects.

Veteran Member

Date Joined May 2005
Total Posts : 511
   Posted 7/9/2008 3:19 PM (GMT -7)   
Yeap about 3 months here too
Living with Crohn's Disease since Jan./2000 but had a few years prior
I'm a true Crohnie with IBS too
Meds I have tried:  Too many to list- LOL
Meds currently on:  Prednisone 20mg tapering  Back up to 30mg  :-(
                           Methotrexate injections once a week 25mg
                           Folic Acid 5mg once a week
No Surgeries

New Member

Date Joined Oct 2007
Total Posts : 9
   Posted 7/9/2008 3:20 PM (GMT -7)   
I appreciate everyone's input; My WBC has been stable so I plan to increase to the target dose (100 mg/d) tomorrow and try and be patient!

Veteran Member

Date Joined Sep 2007
Total Posts : 565
   Posted 7/9/2008 7:00 PM (GMT -7)   
i increased from 25 to 50 and now to 75mgs (i weigh 106lbs) so i am kind of on a high dose for my size. after several months at 50mgs and my tpmt levels were low, i increased to 75mgs, had my tpmt checked again a few months later and barely had a change. i am still about 1/3 away from even hitting the beneficial zone :/ also, you should ask your gi if you still need to take pentasa. my gi said once you hit the point of 6mp, pentasa isn't much help. it's so expensive with little results, at least, that's what i found in my case!

best of luck to you!
.: stephanie :.
33 y/o female diagnosed 8/8/7 with crohn's of the terminal ileum w/ stricture/scarring
meddies: 6mp, percocet, trazodone, ativan, iron, calcium, folic acid & some other vits

Veteran Member

Date Joined Jan 2003
Total Posts : 734
   Posted 7/10/2008 11:29 AM (GMT -7)   
I take 75mg of 6MP a day. This may seem strange but I felt better within days of taking it. I started it for my abcess and it did take about 3-4 months for it to kick in and take care of the aabcess. It is hard when you feel like crap to wait for a med to kick in, but 6MP has been my wonder drug. I have been on it for 5 years now and Pentasa for about 9.
"We can't beat this disease, YET, but we can't let it beat us!"

"Do not worry about tomorrow, for tomorrow will worry about itself. Each day has enough trouble of its own." Matthew 6:34

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