I heard back from my doc at the Mayo today. He said they want me to try Pentasa for a few weeks and see how it does. I'm going to call him back in 3 weeks. I'm taking 2-500 mg/4x day and they are big blue horse pills. When I went to pick it up at the pharmacy there were 3 HUGE bottles! I also got my B12 and needles while I was there so I left with a bag full today!