Irritable Bowel Syndrome is more of a mechanical issue than an inflammatory issue. There are a number of theories as to what is going on in IBS, mostly about the ability of the colon to regulate the flow of waste. The biggest difference between CD and IBS is inflammation. With IBS, there is a lot of cramping going on and you either have diarreah or constipation or both, but there is no immune response going on. IBS seems to be really tied to your emtional health and the foods you eat. In the end, IBS does not leave physical scars on your anatomy like CD or UC. It is uncomfortable (sometimes extremely uncomfortable) and embarrassing but not life threatening or dibilitating like CD and UC.
Wife to 27 y/o diagnosed with Crohn's in August 2006
Possible perianal fistula presence for 2 or more years before dx
Severe perianal fistulazation
Taking Remicade but switching to Humira
Abandoning Humira in hopes that participating in a clinical study for Abatacept will work better