how long til methotrexate works?

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Regular Member

Date Joined May 2006
Total Posts : 229
   Posted 7/24/2008 1:48 PM (GMT -7)   
Well i recently just started the methotrexate injections, 25mg weekly. and I heard it was good to take folic acid with this. So I'm taking 2mg daily. I have had 3 injections so far and i was wondering how long does it take for this medication to work? So far i haven't felt much improvement. Any advice would be great. thanks

Veteran Member

Date Joined Dec 2007
Total Posts : 2113
   Posted 7/24/2008 2:14 PM (GMT -7)   
I started in April (I take 15 mgs orally once per week); I was weaned off prednisone eight weeks later with no ill effects. Tried to wean off pred two weeks before starting mtx and was in so much pain two days later that I called the doc and told her she was right I did need more meds.
So I would say give it at least eight weeks although my doc said it might take three months.
Make sure you drink lots of water and continue taking the folic acid it helps protect you from side effects.

Veteran Member

Date Joined May 2005
Total Posts : 511
   Posted 7/24/2008 2:38 PM (GMT -7)   
I just started on Methotrexate injections 25mg this week (tomorrow) will be 6 and it's kicked in. I'm also on Prednisone tapering down. This week I'm 20mg pred and feeling pretty good. I know its working because I was down to 20mg pred a few weeks ago and was having issues and had to go back up for a few more weeks. Now that I'm back to 20mg pred my joints don't hurt, bowels are good and stomach is good so I know its kicked in.
I'm having problems with side effects and tomorrow when I go see my GI I'm asking him if I can up the folic acid. I've also increased my water
intake (Thank you Sjkly!!)
Living with Crohn's Disease since Jan./2000 but had a few years prior
I'm a true Crohnie with IBS and Arthrities too
Meds I have tried:  Too many to list- LOL
Meds currently on:  Prednisone 20mg tapering
                           Methotrexate injections once a week 25mg
                           Folic Acid 5mg once a week
No Surgeries

Veteran Member

Date Joined Mar 2006
Total Posts : 1354
   Posted 7/24/2008 4:44 PM (GMT -7)   
It took around 4 months for the MTX to kick in for me. Be patient and I hope you get relief from this med. Jo
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