I started taking Azasan back in February. I've been wondering why I haven't seen much benefit from it since I've now been on it for five months. Supposedly, it starts to take a noticeable effect in three months, and hit max effectiveness at six months. So I start to do some research. I've found many places (don't have links handy, sorry) that have said to avoid taking azathioprine and mesalamine and/or mesalazine. I've been taking Pentasa this whole time. So I stopped taking the Pentasa just over a week ago, and I have seen *much* improvement. Not just in bowel problems, but also: less joint pain, less fatigue, less mental fog, more ambition, general overall better feeling of well-being.
For those of you that are also taking azathioprine or 6mp, does your doctor also have you taking some form of mesalamine and/or mesalazine?
The references I've found say to avoid the two together, as the mesalamine can inhibit the TPMT enzyme which is used by the body to convert azathioprine to the active chemical which actually performs the beneficial actions.
Just trying to be a "Regular Member".
Entocort 9 mg/day, Prednisone 20 mg/day, Pentasa 4 gm/day, started Humira 1/22/08, started 100 mg of Azasan (Imuran) 2/20/08. I'm convinced that Prednisone is the root of all evil, and primarily responsible for global warming.