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Regular Member

Date Joined Jan 2006
Total Posts : 303
   Posted 8/7/2008 5:44 PM (GMT -7)   
Is assumed that folks with Chrons disease have too much Tumor nercrosis factor. Is there a test out there that can determne the ammount of TNF in ones system?
This would be a good test before trying a TNF blocker.
29 YO Male
-CD diagnosed in 2005 illieum
-63cm bowel resection in Feb 08
-Steroid dependant following surgery
Humira Start date 8/1/08

Veteran Member

Date Joined Jun 2008
Total Posts : 1058
   Posted 8/7/2008 9:58 PM (GMT -7)   
TNF is a part of the immune response of the body and the presence of TNF indicates that there is some antigen in the system. The assumption is that in Crohn's, the immune response is directed at the body's own tissue and that is the reason for TNF inhibitors being used. That model does not explain the numbers of people who can control Crohn's by controlling their diet, nor does it deal with the people who show only mild symptoms. Using TNF inhibitors does reduce the damage done by the body's immune reaction, so that the active damage is reduced or eliminated. Prednisone also is an anti-inflammatory which suppresses the immune response. It is sometimes tapered off until the patient is no longer taking any. If there were a true auto-immunity, that would be impossible. Cells in the blood retain the immune responses that are created by the body for several years. Once the anti-inflammatory drugs were removed, inflammation would recur at once. I don't think that the doctors really have any idea of what is going on and they don't seem to have a real treatment, just symptom suppression.
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