This may not apply to you at all but I was in my 3rd week of Methotrexate and I developed a low grade fever, shivers and sweats. I was busy at work so while I did see my Dr., I had more important things to do.
After about a week I developed severe cramping. My family Dr thought I was having a bad reaction to the Methotrexate and kept me in the local small town hospital on a regular diet, taking Tylonol Codenes every two hours for the pain. After three days he sent me 350 miles by car to Omaha where my Reumy was just coming off vacation.
I made it 300 miles and became violently ill and finished the trip by ambulance. After several hours in the hospital, I went into shock and my wife got a surgeon to look at me. I had ruptured my colon. They did emergency surgery to clean up the Gangreine and Peritonitis and took out an 8" section of gut. I had an out of body experience and watched the surgery from above. After two weeks in the ICU and another 4 weeks in the hospital, I went home.
If that were to happen again, I would beg for Cipro or Flagyl from the getgo and would have been well in the first week. The Methotrexate and Prednisone had masked the real problem.
Don't make the same mistake I did.
Retired male in late 60's. Perforated Colon in 92. Diagnosed as Ulcerative Colitis in 93. Uncontrolled flareup in 97 dictated J-pouch surgery. 04 Capsule endoscopy diagnosed as Crohns not UC. Emergency surgery in 05 to remove lodged camera capsule. Biopsies positively diagnosed Crohns at that time. 12/06 Unsucessfully tried Naltrexone(LDN). 2/07 developed scleritis of the eye, tearing and detaching the retina. Treated with high doses of Prednisone. 6/07 Thought eye was healing and started taking Entocort counting on the residual (non-systemic portion) as treating the eye. Wrong. In October eye was not stabilized. 11/07 Started Remicade to try and reduce the ocular inflamation of the Scleritis since I had been requiring more and more Prednisone to keep the eye quiet. 12/07, retina tares and detaches again. Started Remicade every 4 weeks plus 20mg of Prednisone per day. Six months and seven infusions later, good eye is back to 20/14. Bad eye is 20/70. Had cataract surgery on June 05 on bad eye. Eye returned to a correctable visionary level of 20/40. Life looks good (literally) today.
Married with 4 grandkids.