I don't know how Osiris plans to layout treatment options, but I can't see how infusing stem cells would be a "long term" ("cure") type of thing since the patient's immune system is already "programmed." The stem cell trials that are giving long term (years) relief is more the type where the patient undergoes chemotherapy to kill their own immune system then is either infused with their own (harvested) or a donor's stem cells. That, in effect, resets the immune system... Prochymal does not do that. (this is all just my understanding.)
The mesenchymal cells in Prochymal are neutral - from a variety of donors and "washed" - and any that are the not the right type are just flushed from the system. But the cells attach to the areas of inflammation when they find it and, it was explained to me, have a bit of immune suppressing qualities at the site. They stop the inflammation process and help rebuild healthy tissue.
I had a second round of infusions, but was re-randomized and got no benefit from the second randomizaton. So, I quit the study which was 3.5 hrs north of me... I was hoping I'd get the high dose and it would "fix" me enough to stick in remission longer. but that was a lot of driving for no benefit and there were to be no further randomizations.
--40 year old female, dx as UC in '04 (1st symptoms in '03), switched to Crohn's in '05, 1 fistula, crohn's colitis, limited to large intestine
--rejected (reaction/didn't work): Asacol, AZA, 6-MP, MTX, Remicade, Humira, prednisone
--methylpred - finally off 6/15/08, tried Prochymal in Phase III study (can't wait til it's approved!)
--started Tysabri 3/21/08
--single mom to 10-yr-old girl