Clinical Trial - ABT-874

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Kaycie
Regular Member


Date Joined Jan 2006
Total Posts : 449
   Posted 9/9/2008 10:00 PM (GMT -7)   
I just got offered this today from my GI. My Remicade at 10mg/kg and 6 weeks has failed me and I'm back up to 25mg of steroids to hold me over until I can qualify and start the trial.

I have all the paperwork and it seems like a great trial because EVERYONE at some point gets the drug. I'm worried about getting the placebo, but after the first 8 weeks, my doc will have a say on who gets drug and who doesn't and in addition, if I'm having symptoms, I will automatically get the max dose of drug.

Anyone else participating in this study or have any other info on it?
Kaycie - Age: 26
Crohn's - Dx Nov 05
Remicade - Next infusion - July 10th - new dose - 10mg/kg
IVF #1 (In-Vitro Fertilization) - Failed
IVF #2 - IVIg, Heparin, Baby Aspirin - TWIN GIRLS!!!
Reagan Dawn - 8/2/07 - Lived 1 hour 27 minutes due to Cloaca, NOT affiliated with my Crohn's
Addison Maria - 8/2/07 - 11 months old


sr5599
Veteran Member


Date Joined Aug 2007
Total Posts : 1202
   Posted 9/10/2008 7:20 AM (GMT -7)   
I have not heard of this, but thanks for bringing it up. I'm going to talk to my doc about it (it's listed through his office) when I go in for my appt next week. I don't know if I'll do it with the fact that I still haven't tried Cimzia. But, it's so good to know there are other options out there.

So, at what point do they start the open label (real drug) phase? How long do the control groups last? Is it phase 2?
--40 year old female, dx as UC in '04 (1st symptoms in '03), switched to Crohn's in '05, 1 fistula, crohn's colitis, limited to large intestine
--rejected (reaction/didn't work): Asacol, AZA, 6-MP, MTX, Remicade, Humira, prednisone
--methylpred - finally off 6/15/08, tried Prochymal in Phase III study (can't wait til it's approved!)
--started Tysabri 3/21/08
--single mom to 10-yr-old girl

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