How long does it take for an Imuran dosage change to work?

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Regular Member

Date Joined Oct 2007
Total Posts : 235
   Posted 9/20/2008 10:53 AM (GMT -7)   
I'm currently on 20 mg/day of prednisone, bi-weekly Humira, and 100 mg/ day of Azasan (6mp, Imuran, whatever you want to call it.) I'm doing fairly well. I'd say about 80% of full remission. Unfortunately, I'm in a job where 100% would really be best. Also, my Doc wants me to attempt to get off the pred all the way, which would be fine with me. However, I don't feel like I'm doing well enough on my current meds to decrease the pred (so far, the only med that I'm 100% sure helps my CD is the pred, and every time I attempt to taper it, I flare). So I'm going to discuss increasing my Azasan dosage with him at my next appointment in October. For those of you with experience with 6mp, Imuran, Azasan, etc., how long does a *dosage adjustment* (*NOT* the initial effects -which are known to be 3+ months-) take to have any noticeable effects? I'm hoping I don't have to wait another three months after a dosage adjustment to start cutting down on the pred. Even at 20 mg/day, I hate the stuff.
I'm a bit disappointed so far (at least with my current dosing) in the Azasan. My doc mentioned "you'll get all the same relief from Azasan as you do with the pred, but without the side effects", which kinda got my hopes up. I do still hope that maybe a dosage adjustment will be the ticket. I know that 40 mg/day of prednisone *completely* relieves all my CD symptoms, and 20 mg/day just barely keeps me out of the bathroom. Maybe the 100 mg/day of Azasan is like 20 mg/day of pred, and there's room on the upside of the dosing schedule.
Just trying to be a "Regular Member".
Entocort 9 mg/day, Prednisone 20 mg/day, Pentasa 4 gm/day, started Humira 1/22/08, started 100 mg of Azasan (Imuran) 2/20/08. I'm convinced that Prednisone is the root of all evil, and primarily responsible for global warming.

Veteran Member

Date Joined Apr 2005
Total Posts : 2346
   Posted 9/20/2008 4:30 PM (GMT -7)   
My drs. always did the prometheus metabolite pro-predict test on me 6 weeks after a dosage change, to see if it had put me in the theraputic level without having any toxicity. I was on 200 mg at my highest.
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