How do you know if Remicade is working??

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Regular Member

Date Joined Jul 2008
Total Posts : 113
   Posted 9/28/2008 4:43 PM (GMT -7)   
Just wondering for those of you on remicade..when it started to work, how you knew it started to work (like did you notice a huge improvement) and if it didn't "work" how long did it take ur dr. to switch u to something else like humira? im on remicade now, just the 3 IVs of the loading dose, and i'm not sure if it's even worked...

Regular Member

Date Joined Sep 2008
Total Posts : 97
   Posted 9/28/2008 6:10 PM (GMT -7)   
I was diagnosed in June and was put on pred and asacol, I got tremendously worse on asacol and ended up in the hospital in late August. My colonoscopy in the hospital was much worse than in June so they insisted I had to get remicade. I was extremely better the next day. From probably 30 bm of nothing but bloody water to less than 10 loose bm in about two or three days. Within a week I was having less than 5 bm with almost no blood. I had the second treatment about a week and a half later. I've had completely normal bm with no blood for the last three weeks since the second treatment and only go once or twice a day, that's normal for me. It worked wonders for me since I was in such bad shape, I ended up being in the hospital for twelve days with a pic line hooked up to TPN, severely anemic and malnourished so I was really pretty ill. I'm just not sure if it's right for me with everything else I've had since the treatments. I've gotten thrush after each one and the second one I got a rash on my face, spots they call petechaie, also having vision changes and muscle/bone stiffnes/soreness. The gastro said it's from the prednisone but I've been on that since June, tapering at this point, and haven't had these problems until after the remicade treatments. I'm calling our insurance nurseline to get their input and checking on a second opinion about all of this.
Hope you at least notice a difference soon and don't end up with the issues I have.

Take care,


Regular Member

Date Joined Oct 2006
Total Posts : 153
   Posted 9/29/2008 9:43 AM (GMT -7)   
I've been dealing with Crohns for the past 8 years (officially) and have been on different antibiotics as well as Pentasa over the years. I've been relatively lucky but was hospitalized once for a blockage and once for an abcess. Although I had diarrhea many times every day, my Crohns was considered mild. Then I developed a fistula at the beginning of this year. My GI had to skip all of the other usual medications due to another medical condition and we went straight to Remicade. I had my first infusion in July and within 3 days the diarrhea had tapered down to once or twice a day and all symptoms of the fistula had disappeared. After the 2nd infusion the diarrhea had stopped all together. After the 3rd infusion my stools were fully formed and all other symptoms of Crohns are gone. I've haven't felt this well in almost 10 years. No side effects that I'm aware of. Remicade rocks!!
People react differently to medications. Sometimes it takes a while for the body to respond. Give it some more time and update your GI. Good luck and I hope you start to feel better soon!

32-year-old female diagnosed with CD in 2001.
Currently taking Pentasa 1g x 4 times daily. Started Remicade July 2008.

Elite Member

Date Joined Sep 2005
Total Posts : 10404
   Posted 10/1/2008 3:27 AM (GMT -7)   
I asked the specialist that very question when I started my Rem infusions. His answer was, "you'll know". And I did. You will too, if it starts to work for you.
Co-Moderator Crohn's Forum.

Regular Member

Date Joined Apr 2008
Total Posts : 163
   Posted 10/1/2008 8:12 AM (GMT -7)   
After my first remicade infusion, felt a sense of improvement in terms of reduced number of D the next day. Within 6 weeks, formed stools for the first time since diagnosis. Unfortunately, had a reaction during the 4th infusion, with difficulty breathing, increased heartrate and extreme abdominal pain, which coincided with an attempt to taper the prednisone.

Was then switched to Humira, which had even better results for me, until it stopped working. I had no major side effects from the Humira, aside from mild swelling/irritation at the injection site and slight fatigue.
Dx Mild Proctitis 7/06 at age 33, Dx Severe Pan Colitis 5/07, Dx Crohn's Colitis 10/07
Failed Asacol, Lialda, 6-MP, Canasa, Rowasa, Entocort, and Remicade, weekly Humira
Late 7/08, down to 5 mg pred, and big flare, Humira failed
2 week hospitalization in 8/08
Now on Pred 25 mg, cyclosporine, percocet, xanax
Surgery scheduled 10/10/08 to get rid of this colon

Regular Member

Date Joined Mar 2008
Total Posts : 223
   Posted 10/1/2008 8:41 AM (GMT -7)   
I am 48 yrs old and was dx with crohn's at 19 yrs.  I have had a colostomy and a perforated esophogas.  I started getting severe joint pain and swelling over the last 4 years and was finally started on Remicade one year ago.  It started working around my second or third infusion.  I have some diarrhea and swelling like a week before the remicade is due but to me that is a lot better than before.  I also take Imuran, but have been without maintenance prednisone for about three months.  I do have to take the large doses of prednisone and taper off every so often, but my doctor gave me instructions on how to do that when I feel it is really needed.  I must tell you it has made a big difference in my life. yeah

Regular Member

Date Joined Nov 2013
Total Posts : 129
   Posted 1/9/2016 2:40 PM (GMT -7)   
I've just had my second Remicade infusion and it has got rid of the bleeding and reduced my bms to 2 to 3 - all good after an acute flare requiring hospitalisation. On 30mg of Pred and tapering. My only concern is that the rectum and sigmoid feel inflamed and painful to the extent that I would normally associate with bleeding, but I'm not. It's quite disconcerting??? Has anyone with uc noticed that?

Just hope the Remicade is working….


Regular Member

Date Joined Jun 2014
Total Posts : 302
   Posted 1/9/2016 3:16 PM (GMT -7)   
I was put in infliximab (remicade) after a major flare hospitalised me... Was on it for three months. Wished with my whole heart for improvement ... But after three months I was back in hospital... Given a colonoscopy ... Told absolutely no improvement (quite the opposite) so moved to Humira. Took about 6 months to see real significant improvement.
Diagnosed: January 2000
Drugs: currently Azathioprine 150mg (Imuran) [15yrs], Humira, B12, Tinzaparin, vitamin D3.
Previous drugs: been through the sweet shop
Bonus probs thanks to Crohns: osteoporosis and blood clots
Age: 49 (but feel over 80 when ill)

Violette Rose
Regular Member

Date Joined Aug 2011
Total Posts : 69
   Posted 1/10/2016 6:07 PM (GMT -7)   
I saw a huge improvement the day after my first infusion! The effects tapered off as the weeks went by and by my next infusion, I was having symptoms again. The day after my treatment, I was back to normal; normal BM, great energy, hungry, no pain. I pretty much feel like a superwoman haha! I'm now every 6 weeks instead of 8 and I feel amazing.
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