The standard/typical dose for 6MP is about 1.5mg per kg of body weight. If you take your weight in pounds and multiply by 0.68, you get the dose. So a dose of 100mg is about right for somebody weighing 150 pounds. If you weigh more, that dose might be a little low - though it's definitely in the ballpark. Since you said you weigh around 180, a dose of 125mg might be a little more appropriate.
Yes, 6MP is a slow-acting drug, unlike prednisone. It usually takes 4-6 weeks to start noticing benefits from 6MP, and it can be as much as 4-6 months to notice full benefit.
If that's too long to wait, you can either stay on prednisone longer, until the 6MP has more time to kick in, or you can move on to Remicade or Humira, which also can take a few weeks but are generally more effective than 6MP, especially for more severe flareups.
Staying on pred longer can sure do wonders for you symptoms; but the longer you're on it, the tougher it is to get off it, and the more long-term side effects you can have. A few weeks is a fairly standard course, but when you start talking several months, that's getting too long. Although some people are on it for years -- and that's only to be done if nothing else works.
As for the nausea, have you noticed it get worse since you started the 6MP? It's often hard to tell if nausea is coming from Crohn's or coming from the medication. Since you had nausea even before starting 6MP, it might be just from your Crohn's. But 6MP does cause nausea in some people. That's why I asked. It's something to consider.
Since you said your test results showed narrowing of the end of the small intestine and beginning of the large, that's *probably* why you've had nausea and vomiting. Narrowing of that area is very common in Crohn's. I'm a little surprised they said for you to be on high fiber with that type of narrowing; usually they recommend LOW fiber, low roughage diets. But everybody is different in the diets they tolerate, so you might just need to experiment and keep a food journal.
Post Edited (beave) : 10/16/2008 5:07:09 PM (GMT-6)