Methotrexate. . . . . ?

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Regular Member

Date Joined Apr 2008
Total Posts : 195
   Posted 10/15/2008 10:30 PM (GMT -7)   
Hey everyone, just wondering if anyone is takin methotrexate? I haven't started it yet, but I will be in a couple of weeks. I have to have a colonscopy to see how my guts are doing after 4 yrs of no supervision by any doctors. It will probably be worse than the last time when I was 18. Im now 22. I definitely feel a lot worse. I was on 6mp for 6 yrs and never did anything for me. My doc says that methotrexate is similar to 6mp, but works different. I am hoping it works. Not looking forward to taking something new. It's been a long time since I have had to try anything new. It will be nice to only have to take it once a week. Well just wondering what the low down is on this drug. Any info and experience would be great. Thanks and hope everyone is having a great day.
Age:22/6"1'/138lb - Diagnosed: 2001 @ age 15 now 22
First time mom as of March 8th 2008
Past drugs: Pentasa, Flagyl, Budesonide, Prednisone, tons of Antibiotics, Didrocal
Past herbal remedies and vitamins:Probiotics, Omega 3&6, Prenatal vitamins, B12, Calcium, iron, vit C, vit D, vit E, Selenium, mineral drops
Current drugs: Valtrex, Warfarin, Prednisone :(, 6mp :( NOT WORKING
Problems:Fissure and Tags on rectum, blood clots, ChronicUTI's, Osteopenia, Ulcers in my decending Colon
No surgeries....yet. Gone through 5 G.I.'s
Procedures: 3 colonoscopies, 1 upper endoscopy, 2 barium swallows, 1 biopsy of the fissure and tag (chron's affected)

Elite Member

Date Joined Sep 2005
Total Posts : 10404
   Posted 10/15/2008 10:37 PM (GMT -7)   
Check out the new meds thread. You can find it under the resources thread at the top of the forum.

Best wishes,

Co-Moderator Crohn's Forum.

Veteran Member

Date Joined Jul 2006
Total Posts : 6927
   Posted 10/16/2008 4:21 AM (GMT -7)   
MTX by injection is about the only med that worked for me.
Forum Co-moderator - Crohn's Disease
...I will find a way, or make one. -Philip Sidney 1554-1586
Make sure your suffering has meaning...
All suggestions/options/opinions are caveated with please consult with your local health care provider...

Regular Member

Date Joined Dec 2007
Total Posts : 414
   Posted 10/16/2008 9:47 AM (GMT -7)   
I've been on methotrexate in tablet form 25mg a week for 6 years now, spent the majority of those 6 years in remission with 2 flare ups since the 1st that lead me to be diagnosed. I'd tried several drugs beforehand and I'd always either be allergic or it just wouldn't work so methotrexate was pretty much my last option as back then infliximab wasnt on the NHS. It takes a while to work - it will not instantly make you feel better! You've got to give it at least 3 months, when I first went on it my inflammation levels halved each month til they were eventually normal. As it is a very low dose of cancer drug it can give you some nasty side effects such as nausea and can make you a bit tired and floaty so its best to take it at night before you sleep so you can sleep through the majority of the side effects but your doc should be able to give you stuff to help if you do get nausea or anything else.

Regular Member

Date Joined Apr 2008
Total Posts : 289
   Posted 10/16/2008 1:59 PM (GMT -7)   
I had my 5th injection of MTX this past Tuesday. My final injection is next week, then I switch to pills.

I had a colon resection in May of this year, when I was finally diagnosed with CD instead of UC. The surgery took away the severe pain I'd had, but left me with most of my symptoms (mostly frequency and loose stools with gas causing mucous). After my 1st MTX shot, I noticed my number of trips to the bathroom dropped significantly and my stools began to form, not solid, but certainly no longer liquid. The few days before my next dose I seem to revert back to looser and numerous, but the days (1-5) after the shot are great.

I've only experienced light nausea. I got an anti-nausea Rx but I've only taken one tablet after the very first shot. The nausea since then is minimal and if I think of something else or eat a cracker or something, I'm good.  I did have long hair (below bra strap) and it was sort of 'shedding' in handfuls when I showered or brushed it so I recently got it cut to chin-length so I don't notice the hair loss/thinning any longer.

I have the ability of single-minded determination and accurate project focu....Hey, look, a cat!
Crohn's and UC are pretty darn crappy, but if you can't laugh at yourself, you'll cry. 
I'd much rather laugh.
2001 Dx'd with UC.  No remission.  5/2008 surgery, removal of 6" of left side colon.  Dx changed to Crohn's.  Remission for 8-9wks after surgery, symptoms returning after resuming 6MP.

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