Does Imuran (Azathioprine) screw up the absorption of other meds?

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Regular Member

Date Joined Jun 2008
Total Posts : 125
   Posted 11/13/2008 12:12 PM (GMT -7)   
I have been on Imuran for several months. Recently, I have noticed the effects of everything from caffeine and cold medicine has drastically increased. I took an Allegra D recently (which before immuran I took every day with no issues). I had not taken it in a while cause my insurance cut me off. I ran out of my usual Zyrtec and took a sample of Alegra D that I had. I thought i was going to crawl out of my skin. I also got the same reaction a few weeks ago when I took a tylenol cold medicine. Finally, I have noticed that my reaction to caffeine has become much more sensitive too.

Overall, I feel jumpy and I HATE that feeling, as I am so prone to anxiety as it is. It just feels like something very physical is happening.

Is this an effect of the immuran?? My hair is starting to fall out more too - Which i know is the imuran.

Help!? What is happening?
35 year old female - Diagnosed w/Crohn's 2002 - Surgery 2004

Currently taking: Pentasa, Entocort, Imuran, Immodium, Zoloft, Wellbutrin, Seroquel

Regular Member

Date Joined Apr 2007
Total Posts : 99
   Posted 11/13/2008 1:54 PM (GMT -7)   
hi, i have been on imuran over three years and i do not have any side effects. I am pregnant and feeling great!!! Take care!!!

Regular Member

Date Joined Aug 2008
Total Posts : 37
   Posted 11/13/2008 3:36 PM (GMT -7)   
I have been taking Imuran for most of 2 years and haven't had any of the issues you describe.

  • CD dx '86. Re-section '93. Dx Crohn's Colitis '98.
  • Participation in Remicade trials (fistulae) late 90's.
  • Manifestations of fissures, fistula, scleritis, polyarthralgia and erythema nodosum.
  • Presently on Imuran, Cipro, Flagyl
  • Remicade (2nd attempt - after 10 yrs - failed).  

Elite Member

Date Joined Sep 2005
Total Posts : 10404
   Posted 11/13/2008 3:46 PM (GMT -7)   
Kam, I don't know, but I can tell you that my mother had the same problem with caffeine when she was on chemotherapy. Maybe it would be a good idea to ask your doctor or pharmacist and see if they can provide a better answer?
Co-Moderator Crohn's Forum.

Forum Moderator

Date Joined Nov 2003
Total Posts : 7122
   Posted 11/13/2008 4:15 PM (GMT -7)   
You might want to discuss your hair loss also with your doctor when you discuss the increase in anxiety feelings. Imuran is a folic acid antagonist. My doctor wrote me a script for folic acid and it has helped with the hair loss.

I noticed that Imuran heightened the effect of alcohol when I first took it. I had a drink for my daughter's birthday a couple days after starting Imuran. Half a margarita and I was practically on my lips!
Moderator Crohn's Disease Forum
CD, Ankylosing Spondylitis, lupus, small fiber peripheral neuropathy, avascular necrosis, peripheral artery disease, degenerative disc disease, and a host of other medical problems.

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